ArticlePLoS computational biology2018
Cell adhesion and fluid flow jointly initiate genotype spatial distribution in biofilms.
Article in PLoS computational biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Cooperative antibiotic response in coupled biofilm and planktonicbioRxiv : the preprint server for biology · 2026Article
- Peptide-based ligand antagonists block a Vibrio cholerae adhesin.FEBS letters · 2026Article
- Disentangling the feedback loops driving spatial patterning in microbial communities.NPJ biofilms and microbiomes · 2025Review
- Bacterial species with different nanocolony morphologies have distinct flow-dependent colonization behaviors.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Simulation and Modeling of the Adhesion ofPathogens (Basel, Switzerland) · 2024Article
- Microfluidic approaches in microbial ecology.Lab on a chip · 2024Review
- Evolution-proof inhibitors of public good cooperation: a screening strategy inspired by social evolution theory.FEMS microbiology reviews · 2022Article
- Founder cell configuration drives competitive outcome within colony biofilms.The ISME journal · 2022Article
- Article
- 'Chain and running' induced by mechanical interactions among cells of different phenotypes in the Bacillus subtilis biofilm.European biophysics journal : EBJ · 2021Article
- Both Pseudomonas aeruginosa and Candida albicans Accumulate Greater Biomass in Dual-Species Biofilms under Flow.mSphere · 2021Article
- Bacterial predation transforms the landscape and community assembly of biofilms.Current biology : CB · 2021Article
- Experimental Designs to Study the Aggregation and Colonization of Biofilms by Video Microscopy With Statistical Confidence.Frontiers in microbiology · 2021Article
- Structured environments foster competitor coexistence by manipulating interspecies interfaces.PLoS computational biology · 2021Article
- Mechanomicrobiology: how bacteria sense and respond to forces.Nature reviews. Microbiology · 2020Review
- Article
- Cellular advective-diffusion drives the emergence of bacterial surface colonization patterns and heterogeneity.Nature communications · 2019Article
- Structured environments fundamentally alter dynamics and stability of ecological communities.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
Corrections and comments
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Authors and funding
5 authors at 5 institutions in 3 countries.
Funding
Abstract
Biofilms are microbial collectives that occupy a diverse array of surfaces. It is well known that the function and evolution of biofilms are strongly influenced by the spatial arrangement of different strains and species within them, but how spatiotemporal distributions of different genotypes in biofilm populations originate is still underexplored. Here, we study the origins of biofilm genetic structure by combining model development, numerical simulations, and microfluidic experiments using the human pathogen Vibrio cholerae. Using spatial correlation functions to quantify the differences between emergent cell lineage segregation patterns, we find that strong adhesion often, but not always, maximizes the size of clonal cell clusters on flat surfaces. Counterintuitively, our model predicts that, under some conditions, investing in adhesion can reduce rather than increase clonal group size. Our results emphasize that a complex interaction between fluid flow and cell adhesiveness can underlie emergent patterns of biofilm genetic structure. This structure, in turn, has an outsize influence on how biofilm-dwelling populations function and evolve.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.