ReviewMolecules (Basel, Switzerland)2018
Synthesis of Theaflavins and Their Functions.
Review in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 124 citations in OpenAlex.
- Medicinal Value ofInternational journal of molecular sciences · 2026Review
- Advances regarding physiological functions and mechanisms of theaflavin‑3,3'‑digallate (Review).Molecular medicine reports · 2026Review
- Fermented Tea and Cognitive Dysfunction in Diabetes: A Novel Perspective on the Gut-Brain AXIS.Food science & nutrition · 2025Review
- A Comprehensive Review of Theaflavins: Physiological Activities, Synthesis Techniques, and Future Challenges.Food science & nutrition · 2025Review
- Diverse Structures of Tea Polyphenols from Rougui Wuyi Rock Tea and Their Potential as Inhibitor of 3C-like Protease.Molecules (Basel, Switzerland) · 2025Article
- Theaflavins attenuate iron overload-induced liver oxidative injury by inhibiting hepatocyte ferroptosis.International journal of biological sciences · 2025Article
- Investigation of the quality ofFood chemistry: X · 2024Article
- Food and Food Waste Antioxidants: Could They Be a Potent Defence against Parkinson's Disease?Antioxidants (Basel, Switzerland) · 2024Review
- Recent Advances Regarding Polyphenol Oxidase inFoods (Basel, Switzerland) · 2024Review
- Polyphenols alleviate metabolic disorders: the role of ubiquitin-proteasome system.Frontiers in nutrition · 2024Review
- Theaflavin -3,3'-digallate/ethanol: a novel cross-linker for stabilizing dentin collagen.Frontiers in bioengineering and biotechnology · 2024Article
- The Effect of Theaflavins on the Gut Microbiome and Metabolites in Diabetic Mice.Foods (Basel, Switzerland) · 2023Article
- Antibacterial Effects of Theaflavins againstFoods (Basel, Switzerland) · 2023Article
- Host-mediated beneficial effects of phytochemicals for prevention of avian coccidiosis.Frontiers in immunology · 2023Article
- Inhibition of α-hemolysin activity of Staphylococcus aureus by theaflavin 3,3'-digallate.PloS one · 2023Article
- The Protective Effect of Theaflavins on the Kidney of Mice with Type II Diabetes Mellitus.Nutrients · 2022Article
- Tea Plant (Nutrients · 2022Review
- The Role of Concomitant Nrf2 Targeting and Stem Cell Therapy in Cerebrovascular Disease.Antioxidants (Basel, Switzerland) · 2022Review
- Investigation of the AzoreanAntioxidants (Basel, Switzerland) · 2022Article
- Plant- and Animal-Based Antioxidants' Structure, Efficacy, Mechanisms, and Applications: A Review.Antioxidants (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Numerous epidemiological and interventional clinical studies have consistently reported that black tea is good for human health. The polyphenolic compound, theaflavin, and its galloyl esters (theaflavins) are the primary red pigments in black tea that possess several health benefits, including fat-reducing and glucose-lowering capabilities and lifestyle-related disease prevention related to anti-obesity, anticancer, anti-atherosclerotic, anti-inflammatory, antiviral, antibacterial, anti-osteoporotic, and anti-dental caries properties. These compounds are produced by key enzymes, such as polyphenol oxidase and peroxidase, from parent green tea catechins present in fresh green tea leaves during the production of black tea leaves or the fermentation of green tea. However, theaflavins are only present in low concentrations in black tea; thus, their extraction from black tea leaves at sufficient levels for use in medical studies has been difficult. To circumvent this issue, different procedures for the synthesis of theaflavins using chemical oxidizing reagents or enzymes have been studied; however, low yields have limited their utility. Recently, however, several biosynthetic methods have been developed for the mass production of theaflavins. Using these methods, the physiological functions of theaflavins in lifestyle-related diseases in mice and humans have also been studied. In this review, we present the synthesis of theaflavins and their health benefits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.