Evidence map›Paper›PMID 29659479›Full record

ReviewDentistry journal2018

Oral Dysbiotic Communities and Their Implications in Systemic Diseases.

Preethi Sudhakara, Abishek Gupta, Anshumouli Bhardwaj, Aruni Wilson

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Dentistry journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Preethi SudhakaraDepartment of Genetic Engineering, SRM University, Chennai 603203, India. miyupreethi@gmail.com.
Abishek GuptaDepartment of Genetic Engineering, SRM University, Chennai 603203, India. abhi.dbs2009@gmail.com.
Anshumouli BhardwajRegional Center for Biotechnology, New Delhi 110029, India. biotechbhardwaj@gmail.com.
Aruni WilsonDivision of Microbiology and Molecular Genetics, School of Medicine, Loma Linda University, Loma Linda, CA 92350, USA. aruniwilson@llu.edu.

Funding

Mechanisms of Porphyromonas gingivalis sialoglycoproteases in virulence andhost interactionsR03DE026526 · NIDCR · LOMA LINDA VETERANS ASSN RESEARCH & EDUC · PI WILSON, ARUNI · 2017 to 2018
$220k
NIDCR NIH HHS R03 DE026526
6 · The paper itself

Abstract

The human body supports the growth of a wide array of microbial communities in various niches such as the oral cavity, gastro-intestinal and urogenital tracts, and on the surface of the skin. These host associated microbial communities include yet-un-cultivable bacteria and are influenced by various factors. Together, these communities of bacteria are referred to as the human microbiome. Human oral microbiome consists of both symbionts and pathobionts. Deviation from symbiosis among the bacterial community leads to “dysbiosis”, a state of community disturbance. Dysbiosis occurs due to many confounding factors that predispose a shift in the composition and relative abundance of microbial communities. Dysbiotic communities have been a major cause for many microbiome related systemic infections. Such dysbiosis is directed by certain important pathogens called the “keystone pathogens”, which can modulate community microbiome variations. One such persistent infection is oral infection, mainly periodontitis, where a wide array of causal organisms have been implied to systemic infections such as cardio vascular disease, diabetes mellitus, rheumatoid arthritis, and Alzheimer’s disease. The keystone pathogens co-occur with many yet-cultivable bacteria and their interactions lead to dysbiosis. This has been the focus of recent research. While immune evasion is one of the major modes that leads to dysbiosis, new processes and new virulence factors of bacteria have been shown to be involved in this important process that determines a disease or health state. This review focuses on such dysbiotic communities, their interactions, and their virulence factors that predispose the host to other systemic implications.

Indexed as

human oral microbiomeoral dysbiosissystemic diseasesyet-un cultivable organisms

Identifiers

PMID29659479
PMCPMC6023521

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.