ArticleJournal of bronchology & interventional pulmonology2018
Needle-based Optical Coherence Tomography to Guide Transbronchial Lymph Node Biopsy.
Article in Journal of bronchology & interventional pulmonology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 24 citations in OpenAlex.
- Tertiary lymphoid structural heterogeneity determines tumour immunity and prospects for clinical application.Molecular cancer · 2024Review
- Diagnostic modalities in the mediastinum and the role of bronchoscopy in mediastinal assessment: a narrative review.Mediastinum (Hong Kong, China) · 2024Review
- Novel diagnostic techniques in interstitial lung disease.Frontiers in medicine · 2023Review
- Research progress on the application of optical coherence tomography in the field of oncology.Frontiers in oncology · 2022Review
- Novel image features of optical coherence tomography for pathological classification of lung cancer: Results from a prospective clinical trial.Frontiers in oncology · 2022Article
- Optical coherence tomography for identification of malignant pulmonary nodules based on random forest machine learning algorithm.PloS one · 2021Article
- Current Clinical and Pre-Clinical Imaging Approaches to Study the Cancer-Associated Immune System.Frontiers in immunology · 2021Review
- Diagnosing colorectal abnormalities using scattering coefficient maps acquired from optical coherence tomography.Journal of biophotonics · 2021Article
- Feasibility of combined optical coherence tomography and autofluorescence imaging for visualization of needle biopsy placement.Journal of biomedical optics · 2020Article
- Advances in Optical Coherence Tomography and Confocal Laser Endomicroscopy in Pulmonary Diseases.Respiration; international review of thoracic diseasesReview
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundTransbronchial needle aspiration (TBNA), often used to sample lymph nodes for lung cancer staging, is subject to sampling error even when performed with endobronchial ultrasound. Optical coherence tomography (OCT) is a high-resolution imaging modality that rapidly generates helical cross-sectional images. We aim to determine if needle-based OCT can provide microstructural information in lymph nodes that may be used to guide TBNA, and improve sampling error.
methodsWe performed ex vivo needle-based OCT on thoracic lymph nodes from patients with and without known lung cancer. OCT imaging features were compared against matched histology.
resultsOCT imaging was performed in 26 thoracic lymph nodes, including 6 lymph nodes containing metastatic carcinoma. OCT visualized lymphoid follicles, adipose tissue, pigment-laden histiocytes, and blood vessels. OCT features of metastatic carcinoma were distinct from benign lymph nodes, with microarchitectural features that reflected the morphology of the carcinoma subtype. OCT was also able to distinguish lymph node from adjacent airway wall.
conclusionsOur results demonstrate that OCT provides critical microstructural information that may be useful to guide TBNA lymph node sampling, as a complement to endobronchial ultrasound. In vivo studies are needed to further evaluate the clinical utility of OCT in thoracic lymph node assessment.
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Registered trials
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