ArticleJournal of magnetic resonance imaging : JMRI2019
Comparing the reproducibility of commonly used magnetic resonance spectroscopy techniques to quantify cerebral glutathione.
Article in Journal of magnetic resonance imaging : JMRI, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis and open-source database for in vivo brain Magnetic Resonance spectroscopy in health and disease.Analytical biochemistry · 2023Pooled it
- Development and in vivo proof-of-concept of delayed alternating nutation tailored excitation point resolved spectroscopy (dante-press): a frequency-selective single voxel spectroscopy sequence applied to in vivo measurements of naa and glu at 7.0 T.Magma (New York, N.Y.) · 2026Article
- Reduced thalamic glutathione in migraine: a MEGA-PRESS spectroscopy study.The journal of headache and pain · 2026Article
- Reliability and Reproducibility of Metabolite Quantification UsingNMR in biomedicine · 2025Article
- Test-retest precision of brain metabolites in healthy participants usingQuantitative imaging in medicine and surgery · 2025Article
- Brain extended and closed forms glutathione levels decrease with age and extended glutathione is associated with visuospatial memory.NeuroImage · 2024Article
- Article
- Meta-analysis and Open-source Database for In Vivo Brain Magnetic Resonance Spectroscopy in Health and Disease.bioRxiv : the preprint server for biology · 2023Article
- Signatures of exposure to childhood trauma in young adults in the structure and neurochemistry of the superior temporal gyrus.Journal of psychopharmacology (Oxford, England) · 2023Article
- Exploring brain glutathione and peripheral blood markers in posttraumatic stress disorder: a combined [1H]MRS and peripheral blood study.Frontiers in psychiatry · 2023Article
- Magnetic resonance spectroscopic correlates of progression free and overall survival in "glioblastoma, IDH-wildtype, WHO grade-4".Frontiers in neuroscience · 2023Article
- Assessment of the Precision in Measuring Glutathione at 3 T With a MEGA-PRESS Sequence in Primary Motor Cortex and Occipital Cortex.Journal of magnetic resonance imaging : JMRI · 2022Article
- Article
- In Vivo Brain GSH: MRS Methods and Clinical Applications.Antioxidants (Basel, Switzerland) · 2021Review
- NAC and Vitamin D Improve CNS and Plasma Oxidative Stress in Neonatal HIE and Are Associated with Favorable Long-Term Outcomes.Antioxidants (Basel, Switzerland) · 2021Article
- Repeatability of proton magnetic resonance spectroscopy of the brain at 7 T: effect of scan time on semi-localized by adiabatic selective refocusing and short-echo time stimulated echo acquisition mode scans and their comparison.Quantitative imaging in medicine and surgery · 2021Article
- Altered Metabolites in the Occipital Lobe in Migraine Without Aura During the Attack and the Interictal Period.Frontiers in neurology · 2021Article
- Multimodal Neuroimaging Study of Visual Plasticity in Schizophrenia.Frontiers in psychiatry · 2021Article
- The Ketogenic Diet Increases In Vivo Glutathione Levels in Patients with Epilepsy.Metabolites · 2020Article
- In vivo detection of γ-glutamyl-transferase up-regulation in glioma using hyperpolarized γ-glutamyl-[1-Scientific reports · 2020Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundCerebral glutathione (GSH), a marker of oxidative stress, has been quantified in neurodegenerative diseases and psychiatric disorders using proton magnetic resonance spectroscopy (MRS). Using a reproducible MRS technique is important, as it minimizes the impact of measurement technique variability on the study results and ensures that other studies can replicate the results. HYPOTHESIS: We hypothesized that very short echo time (TE) acquisitions would have comparable reproducibility to a long TE MEGA-PRESS acquisition, and that the short TE PRESS acquisition would have the poorest reproducibility. STUDY TYPE: Prospective. SUBJECTS/PHANTOMS: Ten healthy adults were scanned during two visits, and six metabolite phantoms containing varying concentrations of GSH and metabolites with resonances that overlap with GSH were scanned once. FIELD STRENGTH/SEQUENCE: At 3T we acquired MRS data using four different sequences: PRESS, SPECIAL, PR-STEAM, and MEGA-PRESS. ASSESSMENT: Reproducibility of each MRS sequence across two visits was assessed. STATISTICAL TESTS: Mean coefficients of variation (CV) and mean absolute difference (AD) were used to assess reproducibility. Linear regressions were performed on data collected from phantoms to examine the agreement between known and quantified levels of GSH.
resultsOf the four techniques, PR-STEAM had the lowest mean CV and AD (5.4% and 7.5%, respectively), implying excellent reproducibility, followed closely by PRESS (5.8% and 8.2%) and SPECIAL (8.0 and 10.1%), and finally by MEGA-PRESS (13.5% and 17.1%). Phantom data revealed excellent fits (R DATA
conclusionOur data suggest that GSH can be quantified reproducibly without the use of spectral editing. LEVEL OF EVIDENCE: 2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;49:176-183.
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