SynthesisJournal of the American Geriatrics Society2018
State of the Science of Neural Systems in Late-Life Depression: Impact on Clinical Presentation and Treatment Outcome.
Synthesis in Journal of the American Geriatrics Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- A randomized controlled trial study of a life review art intervention for older adults living alone.Frontiers in psychology · 2025Trial
- Remission is insufficient: predictors and mechanistic models of recurrence in late-life depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Complex Neurobiological Mechanisms and Risk Factors Underlying Late-Life Depression.Advances in experimental medicine and biology · 2026Review
- Systemic immune-inflammatory index mediates the association between regular walking and depression in the elderly with coronary heart disease.BMC geriatrics · 2025Article
- Altered triple network model connectivity is associated with cognitive function and depressive symptoms in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Observational
- Reconsidering remission in recurrent late-life depression: clinical presentation and phenotypic predictors of relapse following successful antidepressant treatment.Psychological medicine · 2024Article
- Assessing depression recurrence, cognitive burden, and neurobiological homeostasis in late life: Design and rationale of the REMBRANDT Study.Journal of mood and anxiety disorders · 2024Article
- Biological factors influencing depression in later life: role of aging processes and treatment implications.Translational psychiatry · 2023Review
- Executive function deficits and medial temporal lobe atrophy in late-life depression and Alzheimer's disease: a comparative study.Frontiers in psychiatry · 2023Article
- The Effect of Meditation-Based Interventions on Patients with Fatigue Symptoms: A Systematic Review and Meta-Analysis.Psychologica Belgica · 2023Article
- Preliminary Comparison of Subcortical Structures in Elderly Subclinical Depression: Structural Analysis with 3T MRI.Experimental neurobiology · 2021Article
- The Role of Exercise in Management of Mental Health Disorders: An Integrative Review.Annual review of medicine · 2021Review
- Advances in geropsychiatric nursing: A decade in review.Archives of psychiatric nursing · 2020Review
- The Age Limit Does Not Exist: A Pilot Usability Assessment of a SMS-Messaging and Smartwatch-Based Intervention for Older Adults with Depression.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2020Article
- Mechanisms and treatment of late-life depression.Translational psychiatry · 2019Review
- Challenges in Aging, Dementia, and Mental Health: New Knowledge and Energy to Inform Solutions.Journal of the American Geriatrics Society · 2018Article
- Connectivity patterns of the core resting-state networks associated with apathy in late-life depression.Journal of psychiatry & neuroscience : JPNArticle
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2 authors at 2 institutions in 1 country.
Funding
Abstract
Major depression in older adults, or late-life depression (LLD), is a common and debilitating psychiatric disorder that increases the risk of morbidity and mortality. Although the effects of LLD make it important to achieve a diagnosis and start treatment quickly, individuals with LLD are often inadequately or unsuccessfully treated. The latest treatment developments suggest that interventions targeting executive dysfunction and neuroticism, constructs associated with poor response to antidepressants in older adults, are successful in treating LLD. Specific behavioral interventions (computerized cognitive training, mindfulness meditation, aerobic exercise) appear to decrease depressive symptoms and ameliorate executive dysfunction and neuroticism, but we do not fully understand the mechanisms by which these treatments work. We review recent research on neural network changes underlying executive dysfunction and neuroticism in LLD and their association with clinical outcomes (e.g., treatment response, cognitive functioning).
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.