SynthesisJournal of the American Geriatrics Society2018
State of the Science: Apathy As a Model for Investigating Behavioral and Psychological Symptoms in Dementia.
Synthesis in Journal of the American Geriatrics Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- The effect of physical exercise on apathy in older adults: a systematic review and meta-analysis.Frontiers in public health · 2025Pooled it
- A Biopsychosocial Framework for Apathy Following Moderate to Severe Traumatic Brain Injury: A Systematic Review and Meta-analysis.Neuropsychology review · 2024Pooled it
- Novel Technological Solutions for Assessment, Treatment, and Assistance in Mild Cognitive Impairment.Frontiers in neuroinformatics · 2019Pooled it
- Associations between apathy and global cognition in a 5-year follow-up of individuals with Alzheimer's disease.Journal of neuropsychology · 2026Article
- The Impact of Dementia Caregiving on the Health of the Spousal Caregiver.Medicina (Kaunas, Lithuania) · 2026Review
- A multi-site randomized clinical trial of socially assistive robots on engaging older adults with cognitive impairment residing in long-term care settings: A protocol paper.Contemporary clinical trials · 2025Article
- Self- versus caregiver-reported apathy across neurological disorders.Brain communications · 2025Article
- Telemedicine and Disparities in Mental Health Service Use Among Community-Dwelling Older Adults With Alzheimer Disease and Related Dementias.Journal of the American Medical Directors Association · 2024Observational
- Apathy in Lewy body disease and its effects on functional impairment over time.Frontiers in neurology · 2024Article
- Identifying and managing apathy in people with dementia living in nursing homes: a qualitative study.BMC geriatrics · 2023Article
- Experiences and understanding of apathy in people with neurocognitive disorders and their carers: a qualitative interview study.Age and ageing · 2023Article
- The contribution of behavioral features to caregiver burden in FTLD spectrum disorders.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- Person-centered assessment of apathy and resistance to care in people living with dementia: Review of existing measures.Alzheimer's & dementia (New York, N. Y.) · 2022Article
- Apathy is not associated with a panel of biomarkers in older adults with HIV disease.Journal of psychosomatic research · 2022Article
- A Comparison of Behavioral and Psychological Symptoms of Dementia (BPSD) and BPSD Sub-Syndromes in Early-Onset and Late-Onset Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2022Article
- Apathy is associated with poorer abstinence self-efficacy in individuals with methamphetamine dependence.Addictive behaviors reports · 2021Article
- Apathy is Associated with Critical Psychological Determinants of Medication Adherence in HIV Disease.Journal of clinical psychology in medical settings · 2021Article
- Revisiting Apathy in Alzheimer's Disease: From Conceptualization to Therapeutic Approaches.Behavioural neurology · 2021Review
- Advances in geropsychiatric nursing: A decade in review.Archives of psychiatric nursing · 2020Review
- Nomenclature Used by Family Caregivers to Describe and Characterize Neuropsychiatric Symptoms.The Gerontologist · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Apathy is one of the most common and pervasive of the behavioral and psychological symptoms of dementia (BPSDs). Apathy has profound consequences for morbidity, mortality, and caregiver burden. Treatment of apathy has been hindered because of poor understanding of the mechanisms underlying this heterogeneous syndrome. Research has demonstrated that apathy is associated with disruption of the frontal-striatal system in individuals with neurodegenerative disease. As with other BPSDs, these neural mechanisms alone do not completely account for the syndrome; individual, caregiver, and environmental factors also contribute to apathy. In this article, we modify a current conceptual model of the factors contributing to BPSDs to examine determinants of apathy. This integrative model provides a more complete and theoretically informed understanding of apathy, allowing for greater insight into potential targets for research, intervention, and care. We end by proposing an agenda for moving the science of BPSDs in general, and apathy in particular, forward.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.