Evidence map›Paper›PMID 29658956›Full record

ArticleJournal of diabetes, metabolic disorders & control2017

Deletion of the Neurotrophin Receptor p75

Riyaz Mohamed, Ahmed Y Shanab, Azza B El Remessy

Open access · hybridAbstract read
In one paragraph

Article in Journal of diabetes, metabolic disorders & control, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Modulation of p75International journal of molecular sciences · 2021
    Article
  9. Article
  10. Article
  11. Periodic Intensive Insulin Therapy Remains Experimental.Current therapeutic research, clinical and experimental · 2019
    Article
  12. Deletion of p75Scientific reports · 2018
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Riyaz MohamedCharlie Norwood Veterans Affairs Medical Center, USA.
Ahmed Y ShanabCharlie Norwood Veterans Affairs Medical Center, USA.
Azza B El RemessyCharlie Norwood Veterans Affairs Medical Center, USA.
Biomedical Research Foundation · US

Funding

Molecular Mechanisms of diabetic retinopathyR01EY022408 · NEI · UNIVERSITY OF GEORGIA · PI EL-REMESSY, AZZA B · 2012 to 2016
$1.5M
NEI NIH HHS R01 EY022408
6 · The paper itself

Abstract

Diabetic retinopathy is characterized by early stage of retinal neuro-inflammation that triggers development of acellular capillaries and a late stage of pathological neovascularization. Due to limited treatment options, there is a pressing need to develop new therapeutics. Our group discovered that diabetes-impaired processing of the nerve growth factor precursor (proNGF) resulting in its accumulation and its receptor p75

Indexed as

Acellular capillaryApoptosisDiabetesDiabetic retinopathyNeurotrophinp75NTRPericyteRetina

Identifiers

PMID29658956
PMCPMC5898392
OpenAlexW2794133178

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.