ArticleeLife2018
Transcriptomic analyses reveal rhythmic and CLOCK-driven pathways in human skeletal muscle.
Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03906409 (Effect of Nutrient Delivery Pattern on Biological Rhythms in Human Skeletal Muscle), which is not on this map. Cited by 77 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Nutrient Delivery Pattern on Biological Rhythms in Human Skeletal Muscle
Who cites it
77 citing papers in PubMed, 135 citations in OpenAlex.
- Acute sleep loss results in tissue-specific alterations in genome-wide DNA methylation state and metabolic fuel utilization in humans.Science advances · 2018Trial
- Integrated multi-omics analysis reveals breed-specific molecular and metabolic architectures of breast muscle in Cherry Valley, Muscovy, and mule ducks.Poultry science · 2026Article
- Stephanoside B modulates metabolic gene expression and lengthens the circadian bmal1 oscillation period in differentiated myotubes revealed by real-time bioluminescence.Molecular biology reports · 2026Article
- Chrono-Exercise Medicine: Why Biological Timing Matters for Human Health.Biomedicines · 2026Article
- Circadian Regulation of Glucose Metabolism: Implications for Pathogenesis and Chronotherapy of Type 2 Diabetes.Diabetology · 2026Article
- Exercise Timing in Sport: Molecular and Physiological Mechanisms Linking Performance, Recovery, and Biological Cost.International journal of molecular sciences · 2026Review
- Co-expression network analysis reveals repression ofbioRxiv : the preprint server for biology · 2026Article
- Chrono overexpression blunts exercise-induced improvement in muscular glucose metabolism by inhibiting the BMAL1 transcriptional activity in high-fat diet-fed mice.Journal of physiology and biochemistry · 2026Article
- Feeding-regulated glycogen metabolism drives rhythmic liver protein secretion.Nature metabolism · 2026Article
- The Influence of Acute Beta-Hydroxy Beta-Methylbutyrate (HMB) Ingestion on the Human Skeletal Muscle Transcriptome.Nutrients · 2026Article
- Tuned by time: the role of circadian rhythms in metabolic energy sensing and chronotherapy.Annals of medicine · 2025Review
- Defining and detecting global transcriptional amplitude in circadian gene expression.bioRxiv : the preprint server for biology · 2025Article
- Time to Reset: The Interplay Between Circadian Rhythms and Redox Homeostasis in Skeletal Muscle Ageing and Systemic Health.Antioxidants (Basel, Switzerland) · 2025Review
- The Pro-Apoptotic Effect of Glucose Restriction in NSCLC via AMPK-Regulated Circadian Clock Gene Bmal1.Cancer science · 2025Article
- Effects of Chrono-Exercise and Chrono-Nutrition on Muscle Health: Understanding the Molecular Mechanisms Activated by Timed Exercise and Consumption of Proteins and Carbohydrates.Nutrition reviews · 2025Review
- Physiological rhythms and metabolic regulation: Shining light on skeletal muscle.Experimental physiology · 2025Review
- The Link Between Dietary Timing and Exercise Performance Through Adipocyte AMPKα2 Signaling.International journal of molecular sciences · 2025Review
- Muscle peripheral circadian clock drives nocturnal protein degradation via raised Ror/Rev-erb balance and prevents premature sarcopenia.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Human genetic variation determines 24-hour rhythmic gene expression and disease risk.Nature communications · 2025Article
- Characterizing 24-Hour Skeletal Muscle Gene Expression Alongside Metabolic and Endocrine Responses Under Diurnal Conditions.The Journal of clinical endocrinology and metabolism · 2025Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
25 authors at 7 institutions in 3 countries.
Funding
Abstract
Circadian regulation of transcriptional processes has a broad impact on cell metabolism. Here, we compared the diurnal transcriptome of human skeletal muscle conducted on serial muscle biopsies in vivo with profiles of human skeletal myotubes synchronized in vitro. More extensive rhythmic transcription was observed in human skeletal muscle compared to in vitro cell culture as a large part of the in vivo mRNA rhythmicity was lost in vitro. siRNA-mediated clock disruption in primary myotubes significantly affected the expression of ~8% of all genes, with impact on glucose homeostasis and lipid metabolism. Genes involved in GLUT4 expression, translocation and recycling were negatively affected, whereas lipid metabolic genes were altered to promote activation of lipid utilization. Moreover, basal and insulin-stimulated glucose uptake were significantly reduced upon
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.