Evidence map›Paper›PMID 29658880›Full record

ArticleeLife2018

Crystal structure of intraflagellar transport protein 80 reveals a homo-dimer required for ciliogenesis.

Michael Taschner, Anna Lorentzen, André Mourão, Toby Collins, Grace M Freke, Dale Moulding, Jerome Basquin, Dagan Jenkins, Esben Lorentzen

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
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  8. Article
  9. Article
  10. Compartmentalization of Photoreceptor Sensory Cilia.Frontiers in cell and developmental biology · 2021
    Review
  11. Intraflagellar transport trains and motors: Insights from structure.Seminars in cell & developmental biology · 2020
    Review
  12. Review
  13. IFT80 Is Required for Fracture Healing Through Controlling the Regulation of TGF-β Signaling in Chondrocyte Differentiation and Function.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2020
    Article
  14. Review
  15. Generating Mutant Renal Cell Lines Using CRISPR Technologies.Methods in molecular biology (Clifton, N.J.) · 2020
    Article
  16. Cells · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 4 countries.

Michael Taschner *Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Anna Lorentzen *Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
André Mourão *Institute of Structural Biology, Helmholtz Zentrum München, Neuherberg, Germany.
Toby Collins *Genetics and Genomic Medicine, University College London, London, United Kingdom.
Grace M FrekeGenetics and Genomic Medicine, University College London, London, United Kingdom.
Dale MouldingDevelopmental Biology and Cancer Programmes, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.
Jerome BasquinDepartment of Structural Cell Biology, Max-Planck-Institute of Biochemistry, Martinsried, Germany.
Dagan JenkinsGenetics and Genomic Medicine, University College London, London, United Kingdom.
Esben LorentzenDepartment of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.ORCID http://orcid.org/0000-0001-6493-7220
Aarhus University · DKUniversity College London · GBGreat Ormond Street Hospital · GBHelmholtz Zentrum München · DEMax Planck Institute of Biochemistry · DE

Funding

Biotechnology and Biological Sciences Research Council STU100044631Medical Research Council MR/L009978/1
6 · The paper itself

Abstract

Oligomeric assemblies of intraflagellar transport (IFT) particles build cilia through sequential recruitment and transport of ciliary cargo proteins within cilia. Here we present the 1.8 Å resolution crystal structure of the

Indexed as

Organelle BiogenesisBacterial ProteinsCarrier ProteinsChlamydomonasCiliaCRISPR-Cas SystemsCrystallography, X-RayFrameshift MutationGene EditingProtein MultimerizationBacterial ProteinsCarrier Proteinscell biologyChlamydomonas reinhardtiiciliopathiesCiliumIFT80Intraflagelllar transportmolecular biophysicsmouseprotein structurestructural biology

Identifiers

PMID29658880
PMCPMC5931796
OpenAlexW2802344357

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.