ArticleMolecular medicine reports2018
Age‑dependent decreases in insulin‑like growth factor‑I and its receptor expressions in the gerbil olfactory bulb.
Article in Molecular medicine reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Article
- Neural Stem Cell-based Regenerative Therapy: A New Approach to Diabetes Treatment.Endocrine, metabolic & immune disorders drug targets · 2024Review
- The Organization of Somatostatin-Immunoreactive Cells in the Visual Cortex of the Gerbil.Biomedicines · 2022Article
- Comparison of age-dependent alterations in thioredoxin 2 and thioredoxin reductase 2 expressions in hippocampi between mice and rats.Laboratory animal research · 2021Article
- Dose-Dependent Effects of Insulin-Like Growth Factor 1 in the Aged Olfactory Epithelium.Frontiers in aging neuroscience · 2018Article
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insulin‑like growth factor‑I (IGF‑I) is a multifunctional protein present in the central nervous system. A number of previous studies have revealed alterations in IGF‑I and its receptor (IGF‑IR) expression in various regions of the brain. However, there are few reports on age‑dependent alterations in IGF‑I and IGF‑IR expressions in the olfactory bulb, which contains the secondary neurons of the olfactory system. The present study examined the cellular morphology in the olfactory bulb by using cresyl violet (CV) staining at postnatal month (PM) 3 in the young group, PM 6 in the adult group and PM 24 in the aged group in gerbils. In addition, detailed examinations were performed of the protein levels and immunoreactivities of IGF‑I and IGF‑IR in the olfactory bulb in each group. There were no significant changes in the cellular morphology between the three groups. The protein levels and immunoreactivities of the IGF‑I and IGF‑IR were the highest in the young group and they decreased with age. He protein levels and immunoreactivities of the IGF‑I and IGF‑IR were the lowest in the aged group. In brief, our results indicate that IGF‑I and IGF‑IR expressions are strong in young olfactory bulbs and significantly reduced in aged olfactory bulbs. In conclusion, subsequent decreases in IGF‑I and IGF‑IR expression with age may be associated with olfactory decline. Further studies are required to investigate the roles of IFG‑I and IGF‑IR in disorders of the olfactory system.
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