ArticlePhysics in medicine and biology2018
Multi-resolution simulation of focused ultrasound propagation through ovine skull from a single-element transducer.
Article in Physics in medicine and biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 70 citations in OpenAlex.
- Integrating temperature-dependent tissue properties into focused ultrasound computational models for enhanced treatment planning.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2026Article
- Imaging the brain by traversing the skull with light and sound.Nature biomedical engineering · 2025Review
- A comparative study of experimental and simulated ultrasound beam propagation through cranial bones.Physics in medicine and biology · 2025Article
- Article
- SCOUT: Skull-Corrected Optimization for Ultrasound Transducers.Bioengineering (Basel, Switzerland) · 2024Article
- Robust deep learning estimation of cortical bone porosity from MR T1-weighted images for individualized transcranial focused ultrasound planning.medRxiv : the preprint server for health sciences · 2024Article
- Focused ultrasound heating in brain tissue/skull phantoms with 1 MHz single-element transducer.Journal of ultrasound · 2024Article
- Article
- Non-invasive enhancement of intracortical solute clearance using transcranial focused ultrasound.Scientific reports · 2023Article
- Numerical and experimental evaluation of low-intensity transcranial focused ultrasound wave propagation using human skulls for brain neuromodulation.Medical physics · 2023Article
- A transducer positioning method for transcranial focused ultrasound treatment of brain tumors.Frontiers in neuroscience · 2023Article
- Transcranial focused ultrasound stimulation of cortical and thalamic somatosensory areas in human.PloS one · 2023Article
- Enhancement of cerebrospinal fluid tracer movement by the application of pulsed transcranial focused ultrasound.Scientific reports · 2022Article
- A Comparative Feasibility Study for Transcranial Extracorporeal Shock Wave Therapy.Biomedicines · 2022Article
- Effects of focused ultrasound pulse duration on stimulating cortical and subcortical motor circuits in awake sheep.PloS one · 2022Article
- Transcranial focused ultrasound modulates cortical and thalamic motor activity in awake sheep.Scientific reports · 2021Article
- Safety Review and Perspectives of Transcranial Focused Ultrasound Brain Stimulation.Brain & NeuroRehabilitation · 2021Review
- Spherical Array System for High-Precision Transcranial Ultrasound Stimulation and Optoacoustic Imaging in Rodents.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021Article
- Skull acoustic aberration correction in photoacoustic microscopy using a vector space similarity model: a proof-of-concept simulation study.Biomedical optics express · 2020Article
- Focused Ultrasound Platform for Investigating Therapeutic Neuromodulation Across the Human Hippocampus.Ultrasound in medicine & biology · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Transcranial focused ultrasound (tFUS) is emerging as a non-invasive brain stimulation modality. Complicated interactions between acoustic pressure waves and osseous tissue introduce many challenges in the accurate targeting of an acoustic focus through the cranium. Image-guidance accompanied by a numerical simulation is desired to predict the intracranial acoustic propagation through the skull; however, such simulations typically demand heavy computation, which warrants an expedited processing method to provide on-site feedback for the user in guiding the acoustic focus to a particular brain region. In this paper, we present a multi-resolution simulation method based on the finite-difference time-domain formulation to model the transcranial propagation of acoustic waves from a single-element transducer (250 kHz). The multi-resolution approach improved computational efficiency by providing the flexibility in adjusting the spatial resolution. The simulation was also accelerated by utilizing parallelized computation through the graphic processing unit. To evaluate the accuracy of the method, we measured the actual acoustic fields through ex vivo sheep skulls with different sonication incident angles. The measured acoustic fields were compared to the simulation results in terms of focal location, dimensions, and pressure levels. The computational efficiency of the presented method was also assessed by comparing simulation speeds at various combinations of resolution grid settings. The multi-resolution grids consisting of 0.5 and 1.0 mm resolutions gave acceptable accuracy (under 3 mm in terms of focal position and dimension, less than 5% difference in peak pressure ratio) with a speed compatible with semi real-time user feedback (within 30 s). The proposed multi-resolution approach may serve as a novel tool for simulation-based guidance for tFUS applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.