Evidence map›Paper›PMID 29658324›Full record

ArticleAmyotrophic lateral sclerosis & frontotemporal degeneration2018

Prediagnostic body size and risk of amyotrophic lateral sclerosis death in 10 studies.

Éilis J O'Reilly, Molin Wang, Hans-Olov Adami, Alvaro Alonso, Leslie Bernstein, Piet van den Brandt, Julie Buring, Sarah Daugherty, Dennis Deapen, D Michal Freedman and 8 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Amyotrophic lateral sclerosis & frontotemporal degeneration, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
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  5. Review
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  7. Article
  8. Altered Bioenergetics and Metabolic Homeostasis in Amyotrophic Lateral Sclerosis.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022
    Review
  9. Review
  10. Review
  11. Pre-diagnostic plasma lipid levels and the risk of amyotrophic lateral sclerosis.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2021
    Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 9 institutions in 8 countries.

Éilis J O'Reillya Department of Nutrition , Harvard T.H. Chan School of Public Health , Boston , MA , USA.
Molin Wangc Channing Division of Network Medicine , Brigham and Women's Hospital and Harvard Medical School , Boston , MA , USA.
Hans-Olov Adamie Department of Medical Epidemiology and Biostatistics , Karolinska Institutet , Stockholm , Sweden.
Alvaro Alonsof Department of Epidemiology , Rollins School of Public Health, Emory University , Atlanta , GA , USA.
Leslie Bernsteing Division of Cancer Etiology, Department of Population Science , Beckman Research Institute and City of Hope National Medical Center , Duarte , CA , USA.
Piet van den Brandth Department of Epidemiology, School for Oncology and Developmental Biology (GROW) , Maastricht University , Maastricht , The Netherlands.ORCID 0000-0001-8781-8099
Julie Buringd Department of Epidemiology , Harvard T.H. Chan School of Public Health , Boston , MA , USA.
Sarah Daughertyj CER Methods & Infrastructure , Patient-Centered Outcomes Research Institute , Washington, DC , USA.
Dennis Deapeng Division of Cancer Etiology, Department of Population Science , Beckman Research Institute and City of Hope National Medical Center , Duarte , CA , USA.
D Michal Freedmank Division of Cancer Epidemiology and Genetics , National Cancer Institute , Rockville , MD , USA.
Dallas R Englishl Cancer Epidemiology Centre, Cancer Council of Victoria , Melbourne , Australia.
Graham G Gilesl Cancer Epidemiology Centre, Cancer Council of Victoria , Melbourne , Australia.
Niclas Håkanssonn Division of Nutritional Epidemiology , National Institute of Environmental Medicine, Karolinska Institutet , Stockholm , Sweden.
Tobias Kurthd Department of Epidemiology , Harvard T.H. Chan School of Public Health , Boston , MA , USA.
Catherine Schairerk Division of Cancer Epidemiology and Genetics , National Cancer Institute , Rockville , MD , USA.
Elisabete Weiderpasse Department of Medical Epidemiology and Biostatistics , Karolinska Institutet , Stockholm , Sweden.
Alicja Wolkn Division of Nutritional Epidemiology , National Institute of Environmental Medicine, Karolinska Institutet , Stockholm , Sweden.
Stephanie A Smith-Warnera Department of Nutrition , Harvard T.H. Chan School of Public Health , Boston , MA , USA.
Karolinska Institutet · SEBrigham and Women's Hospital · USCity Of Hope National Medical Center · USHarvard University · USNational Cancer Institute · USThe University of Melbourne · AUEmory University · USMaastricht University · NLPatient-Centered Outcomes Research Institute · US

Funding

Validity of Diet and Activity Measures in WomenP01CA055075 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI WILLETT, WALTER C. · 1991 to 2009
$41.8M
Pooling of Prospective Studies of Diet, Lifestyle and ALSR01NS072494 · NINDS · HARVARD SCHOOL OF PUBLIC HEALTH · PI O'REILLY, EILIS · 2011 to 2013
$524k
NCI NIH HHS P01 CA055075NINDS NIH HHS R01 NS072494
6 · The paper itself

Abstract

OBJECTIVES AND

methodsUsing pooled multivariable-adjusted rate ratios (RR), we explored relationships between prediagnostic body-mass-index (BMI), waist-to-hip-ratio (WHR), and weight-gain during adulthood, and ALS in 419,894 women and 148,166 men from 10 community-based cohorts in USA, Europe, and Australia; 428 ALS deaths were documented in women and 204 in men.

resultsHigher mid-to-later adulthood BMI was associated with lower ALS mortality. For 5 kg/m

conclusionsThese findings confirm somewhat conflicting, underpowered evidence that adiposity is inversely associated with ALS. We newly demonstrate that weight-gain during adulthood is strongly predictive of lower ALS risk.

Indexed as

Body Mass IndexAdolescentAdultAgedAged, 80 and overAge FactorsAmyotrophic Lateral SclerosisAnthropometryCohort StudiesFemaleHumansInternational CooperationMaleMiddle AgedSex FactorsYoung AdultAmyotrophic lateral sclerosisbody mass indexwaist-to-hip ratioweight gain

Identifiers

PMID29658324
PMCPMC6423444
OpenAlexW2799901591

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.