ArticleBMJ open ophthalmology2018
Relationship between electronically measured medication adherence and vision-related quality of life in a cohort of patients with open-angle glaucoma.
Article in BMJ open ophthalmology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- African American patient-provider communication about glaucoma vision quality-of-life.Eye (London, England) · 2024Trial
- Investigation of visual and physical factors associated with inadequate instillation of eyedrops among patients with glaucoma.PloS one · 2021Trial
- Vision-Related Quality of Life Among Glaucoma Patients in Saudi Arabia:Sultan Qaboos University medical journal · 2025Article
- Comparing the Effectiveness and Adherence between Fixed and Non-Fixed Dorzolamide/Timolol Maleate in Open-Angle Glaucoma Patients in Hospital Universiti Sains Malaysia.The Malaysian journal of medical sciences : MJMS · 2023Article
- Review of glaucoma medication adherence monitoring in the digital health era.The British journal of ophthalmology · 2023Review
- Assessing Health Care Burden in Glaucoma Patients with and Without Physical or Mental Comorbidities.Journal of managed care & specialty pharmacy · 2020Article
- Investigation of medication adherence and reasons for poor adherence in patients on long-term glaucoma treatment regimes.Patient preference and adherence · 2019Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate whether electronically measured medication adherence is associated with vision-related quality of life (VRQoL) in patients with open-angle glaucoma. METHODS AND ANALYSIS: This is a 3-year prospective cohort study of 79 subjects with open-angle glaucoma at a Veterans Affairs medical centre. Participants returned a medication event monitoring system (MEMS) for their glaucoma eye-drops and had at least two visits with glaucoma during the study period. Those taking less than 80% of prescribed glaucoma medication doses were considered to be non-adherent. Subjects were interviewed using the National Eye Institute's Visual Function Questionnaire-25 (VFQ-25) at baseline and after 3 years.
resultsThirty per cent (n=24/79) of participants took less than 80% of prescribed doses of their glaucoma medications at baseline. Patients who did not adhere to their medications at baseline had lower mean composite VFQ-25 scores at baseline (70.66±20.50 vs 75.91±19.12, standardised mean difference=0.27) and after 3 years (71.68±21.93 vs 76.25±21.67, standardised mean difference=0.21). Visual acuity (P=0.03), but not visual field severity (P=0.13) or medication adherence (P=0.30), was significantly associated with composite VFQ-25 score in an adjusted model.
conclusionsSubjects who were non-adherent to their glaucoma medications at baseline as assessed by a MEMS device reported lower VRQoL than adherent subjects at baseline and after 3 years. However, visual acuity was significantly associated with VRQoL. Future studies should assess whether improved adherence to eye-drops impacts VRQoL in patients with glaucoma.
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