ArticleAnnals of psychiatry and mental health2017
Early Life Stress Alters Adult Inflammatory Responses in a Mouse Model for Depression.
Article in Annals of psychiatry and mental health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 21 citations in OpenAlex.
- Mechanisms of Maternal Diet-Induced Obesity Affecting the Offspring Brain and Development of Affective Disorders.Metabolites · 2023Review
- Early-life stress and dietary fatty acids impact the brain lipid/oxylipin profile into adulthood, basally and in response to LPS.Frontiers in immunology · 2022Article
- Review
- Early postnatal stress impairs insulin secretion in response to psychological stress in adult rats.Journal of endocrinological investigation · 2021Article
- Neuronal changes and cognitive deficits in a multi-hit rat model following cumulative impact of early life stressors.Biology open · 2020Article
- Sex-Specific Effects of Early Life Stress on Brain Mitochondrial Function, Monoamine Levels and Neuroinflammation.Brain sciences · 2020Article
- Childhood adversity and mechanistic links to hypertension risk in adulthood.British journal of pharmacology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Increased levels of pro-inflammatory cytokines and hypothalamic pituitary axis (HPA) activity are strongly associated with depression. Childhood stress and trauma predispose individuals for increased inflammatory tone and major depression in later life, suggesting that early life reprogramming of the stress/immune axis may be involved in the pathogenesis of depression. In this study, we are using a short duration neonatal maternal separation stress (MS) paradigm in mice to test if early life stress can impact plasma and brain inflammatory tone into adulthood. We use ELISA assays to investigate levels of the pro-inflammatory cytokines IL-1beta, IL-2, IL-6 and TNF-alpha, in both plasma and brain tissue of mice exposed to MS (STR), their unseparated littermates (LMC) and unhandled age matched controls (AMC). Cytokine levels are assessed in male and female adult mice with and without a bacterial lipopolysaccharide (LPS) induced immune challenge. We present evidence that stress exposure, during the first week of life, predisposes both male and female mice for increased inflammatory cytokine secretion, peripherally and in brain tissue, upon adult exposure to lipopolysaccharide (LPS).
Indexed as
Identifiers
29657960PMC5898393W3008272135What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.