Evidence map›Paper›PMID 29657901›Full record

ArticleACS macro letters2018

Triggerable Multivalent Glyconanoparticles for Probing Carbohydrate-Carbohydrate Interactions.

Sangho Won, Steven Hindmarsh, Matthew I Gibson

Abstract read
In one paragraph

Article in ACS macro letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Lectin andMolecules (Basel, Switzerland) · 2021
    Article
  3. Article
  4. Glycan Nanobiosensors.Nanomaterials (Basel, Switzerland) · 2020
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sangho WonDepartment of Chemistry, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, U.K.
Steven HindmarshDepartment of Physics, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, U.K.
Matthew I GibsonDepartment of Chemistry, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, U.K.

Funding

European Research Council 638661
6 · The paper itself

Abstract

Carbohydrate-carbohydrate interactions are proposed to be biologically significant but have lower affinities than the well-studied carbohydrate-protein interactions. Here we introduce multivalent glyconanostructures where the surface expression of lactose can be triggered by an external stimulus, and a gold nanoparticle core enables colorimetric signal outputs to probe binding. Macromolecular engineering of a responsive polymer "gate" enables the lactose moieties to be presented only when an external stimulus is present, mimicking how nature uses enzymes to dynamically regulate glycan expression. Two different carbohydrate-carbohydrate interactions are investigated using this tool.

Identifiers

PMID29657901
PMCPMC5894439

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.