Evidence map›Paper›PMID 29657884›Full record

ArticleNano biomedicine and engineering2017

Ultra-Rapid Crystallization of L-alanine Using Monomode Microwaves, Indium Tin Oxide and Metal-Assisted and Microwave-Accelerated Evaporative Crystallization.

Carisse Lansiquot, Zainab Boone-Kukoyi, Raquel Shortt, Nishone Thompson, Hillary Ajifa, Bridgit Kioko, Edward Ned Constance, Travis Clement, Birol Ozturk, Kadir Aslan

Abstract read
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Article in Nano biomedicine and engineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Carisse LansiquotDepartment of Chemistry, Morgan State University, 1700 East Cold Spring Lane, Baltimore, MD 21209, USA.
Zainab Boone-KukoyiDepartment of Chemistry, Morgan State University, 1700 East Cold Spring Lane, Baltimore, MD 21209, USA.
Raquel ShorttDepartment of Chemistry, Morgan State University, 1700 East Cold Spring Lane, Baltimore, MD 21209, USA.
Nishone ThompsonDepartment of Chemistry, Morgan State University, 1700 East Cold Spring Lane, Baltimore, MD 21209, USA.
Hillary AjifaDepartment of Chemistry, Morgan State University, 1700 East Cold Spring Lane, Baltimore, MD 21209, USA.
Bridgit KiokoDepartment of Chemistry, Morgan State University, 1700 East Cold Spring Lane, Baltimore, MD 21209, USA.
Edward Ned ConstanceDepartment of Chemistry, Morgan State University, 1700 East Cold Spring Lane, Baltimore, MD 21209, USA.
Travis ClementDepartment of Chemistry, Morgan State University, 1700 East Cold Spring Lane, Baltimore, MD 21209, USA.
Birol OzturkDepartment of Physics and Engineering Physics, Morgan State University, 1700 East Cold Spring Lane, Baltimore, MD 21209, USA.
Kadir AslanDepartment of Chemistry, Morgan State University, 1700 East Cold Spring Lane, Baltimore, MD 21209, USA.

Funding

Project-002UL1GM118973 · NIGMS · MORGAN STATE UNIVERSITY · PI KAMANGAR, FARIN · 2015 to 2023
$18.8M
NIGMS NIH HHS UL1 GM118973
6 · The paper itself

Abstract

The use of indium tin oxide (ITO) and focused monomode microwave heating for the ultra-rapid crystallization of L-alanine (a model amino acid) is reported. Commercially available ITO dots (< 5 mm) attached to blank poly(methyl)methacrylate (PMMA, 5 cm in diameter with 21-well silicon isolators: referred to as the iCrystal plates) were found to withstand prolonged microwave heating during crystallization experiments. Crystallization of L-alanine was performed at room temperature (a control experiment), with the use of two microwave sources: a 2.45 GHz conventional microwave (900 W, power level 1, a control experiment) and 8 GHz (20 W) solid state, monomode microwave source with an applicator tip that focuses the microwave field to a 5-mm cavity. Initial appearance of L-alanine crystals and on iCrystal plates with ITO dots took 47 ± 2.9 min, 12 ± 7.6 min and 1.5 ± 0.5 min at room temperature, using a conventional microwave and focused monomode microwave heating, respectively. Complete evaporation of the solvent using the focused microwaves was achieved in 3.2 ± 0.5 min, which is ~52-fold and ~172-fold faster than that observed at room temperature and using conventional microwave heating, respectively. The size and number of L-alanine crystals was dependent on the type of the 21-well iCrystal plates and the microwave heating method: 33 crystals of 585 ± 137 μm in size at room temperature > 37 crystals of 542 ± 100 μm in size with conventional microwave heating > 331 crystals of 311 ± 190 μm in size with focused monomode microwave. FTIR, optical microscopy and powder X-ray diffraction analysis showed that the chemical composition and crystallinity of the L-alanine crystals did not change when exposed to microwave heating and ITO surfaces. In addition, theoretical simulations for the binding of L-alanine molecules to ITO and other metals showed the predicted nature of hydrogen bonds formed between L-alanine and these surfaces.

Indexed as

Evaporative crystallizationITOMicrowave heatingSilver island films

Identifiers

PMID29657884
PMCPMC5897105

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