Stress-Adaptive Responses Associated with High-Level Carbapenem Resistance in KPC-Producing

Sheila Adams-Sapper, Adam Gayoso, Lee W Riley

Open access · hybridAbstract read

In one paragraph

Article in Journal of pathogens, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it

0cells of the map it votes in

6citing papers in PubMed

0.2field-weighted citation impact, top 61% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

Antibiotic Resistance inAntibiotics (Basel, Switzerland) · 2026
Review
Insight into the Mechanisms and Clinical Relevance of Antifungal Heteroresistance.Journal of fungi (Basel, Switzerland) · 2025
Review
In-Human Multiyear Evolution of Carbapenem-Resistant Klebsiella pneumoniae Causing Chronic Colonization and Intermittent Urinary Tract Infections: A Case Study.mSphere · 2022
Article
Pathway Driven Target Selection inFrontiers in cellular and infection microbiology · 2022
Article
Emerging Transcriptional and Genomic Mechanisms Mediating Carbapenem and Polymyxin Resistance inmSystems · 2020
Review
Polymyxins-Curcumin Combination Antimicrobial Therapy: Safety Implications and Efficacy for Infection Treatment.Antioxidants (Basel, Switzerland) · 2020
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Sheila Adams-SapperSchool of Public Health, Division of Infectious Diseases and Vaccinology, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0002-8580-8097

Adam GayosoSchool of Public Health, Division of Infectious Diseases and Vaccinology, University of California, Berkeley, Berkeley, CA, USA.

Lee W RileySchool of Public Health, Division of Infectious Diseases and Vaccinology, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0001-9916-3894

University of California, Berkeley · USColumbia University · US

Funding

Pacific Biosciences PacBio RS Single Molecule Real Time SequencerS10OD018174 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI ROKHSAR, DANIEL SOLEYMAN · 2014 to 2014

$600k

NIH HHS S10 OD018174

6 · The paper itself

Abstract

Carbapenem-resistant Enterobacteriaceae (CRE) organisms have emerged to become a major global public health threat among antimicrobial resistant bacterial human pathogens. Little is known about how CREs emerge. One characteristic phenotype of CREs is heteroresistance, which is clinically associated with treatment failure in patients given a carbapenem. Through

Identifiers

PMID29657865

DOI10.1155/2018/3028290

PMCPMC5883989

OpenAlexW2793161112

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.