ArticleRMD open2018
Paradoxical arthritis occurring during anti-TNF in patients with inflammatory bowel disease: histological and immunological features of a complex synovitis.
Article in RMD open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Identification and Validation of ISG20 as a Shared Immune-Related Crosstalk Marker in Rheumatoid Arthritis and Inflammatory Bowel Disease.Journal of inflammation research · 2026Article
- Rheumatoid Arthritis That Developed in a Patient with Ulcerative Colitis During Adalimumab Therapy: A Case Report and Literature Review.Internal medicine (Tokyo, Japan) · 2025Review
- Integrative pharmacovigilance and AI-based framework uncovers potential drug triggers in juvenile idiopathic arthritis.Frontiers in immunology · 2025Article
- Insights into New-onset Arthritis in Patients with Hidradenitis Suppurativa.Acta dermato-venereologica · 2024Article
- Effectiveness and safety of adalimumab in patients with intestinal Behçet's disease: a real-world prospective observational study in South Korea.BMC gastroenterology · 2023Observational
- Updates on ankylosing spondylitis: pathogenesis and therapeutic agents.Journal of rheumatic diseases · 2023Review
- Cytokines in Spondyloarthritis and Inflammatory Bowel Diseases: From Pathogenesis to Therapeutic Implications.International journal of molecular sciences · 2023Review
- Articular manifestations in patients with inflammatory bowel diseases treated with anti-TNF.RMD open · 2022Article
- New-Onset Psoriatic Arthritis under Biologics in Psoriasis Patients: An Increasing Challenge?Biomedicines · 2021Article
- Review
- Paradoxical Arthralgia Secondary to Anti-Tumor-Necrosis-Factor Alpha Therapy in Crohn's Disease.Cureus · 2021Article
- Novel trends with biologics in inflammatory bowel disease: sequential and combined approaches.Therapeutic advances in gastroenterology · 2021Review
- Musculoskeletal Clinical and Imaging Manifestations in Inflammatory Bowel Diseases.Open medicine (Warsaw, Poland) · 2019Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveParadoxical arthritis under tumour necrosis factor inhibitor (TNF-i) for inflammatory bowel disease (IBD) has been described. This study aims to evaluate the histological features of paired synovial tissue (ST) and colonic mucosa (CM) tissue in patients with IBD developing paradoxical arthritis under TNF-i.
methodsPatients with IBD without history of coexisting joint involvement who developed arthritis under TNF-i were enrolled. Each patient underwent ST biopsy and ileocolonoscopy with CM biopsies. ST and CM paired samples were stained through immunohistochemistry (IHC) for CD68, CD21, CD20, CD3 and CD117. Clinical and immunological parameters (anticitrullinated peptides antibodies (ACPA)-immunoglobulin (Ig)M/IgA rheumatoid factor (RF)) were collected. Psoriatic arthritis (PsA) and ACPA/IgM-RF/IgA-RF negative rheumatoid arthritis (RA) were enrolled as comparison.
results10 patients with IBD (age 46.0±9.7 years, 13.2±9.9 years of disease duration, 2.5±1.6 years of TNF-i exposure, six with Crohn's disease and four with ulcerative colitis, respectively) were studied. At ST level, IHC revealed that patients with IBD with paradoxical arthritis showed more similar histological findings in terms of synovial CD68
conclusionPatients with IBD may develop histologically proven synovitis during TNF-i, comparable to PsA. The inhibition of inflammatory pathways alternative to TNF (IL12/1L23) may be an effective therapeutic option for severe paradoxical articular manifestations.
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