ArticlePrzeglad gastroenterologiczny2018
Efficacy and safety of pegylated interferon α and ribavirin in patients monoinfected with HCV genotype 4.
Article in Przeglad gastroenterologiczny, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionDual therapy (PegIFN and ribavirin) (DT) was the standard of care in patients infected with HCV genotype 4 (HCV-4) until 2014. Nowadays, new treatment options are available including interferon (IFN)-based and other IFN-free regimens.
aimTo assess the efficacy (SVR24) and safety of DT and the selected predictor factors of SVR in HCV-4 infected patients. MATERIAL AND
methodsOne hundred and twelve patients (62 men) of median age 23 years were treated with DT for 48/72 weeks (107/5) in the years 2006-2014. Most of them were treatment naïve (80.4%) and with fibrosis F ≤ 2 (83.1%). To select a subset of independent predictors of SVR Logistic Regression Analysis was applied.
resultsSVR24 was achieved in 46/112 (41.1%) patients. The mean viral load was 5.55 log
conclusionsSVR24 was low. Loss of weight was a new positive predictive factor of SVR found in our study. Most of the AEs were typical of those previously reported for DT.
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