ArticleExpert review of ophthalmology2016
What rates of glaucoma progression are clinically significant?
Article in Expert review of ophthalmology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00221897 (Diagnostic Innovations in Glaucoma Study), which is not on this map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Diagnostic Innovations in Glaucoma Study
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Complications of Myopia: A Review and Meta-Analysis.Investigative ophthalmology & visual science · 2020Pooled it
- Glaucoma Rehabilitation Using ElectricAI Transcranial Stimulation (GREAT)-Optimizing Stimulation Protocol for Vision Enhancement Using an RCT.Translational vision science & technology · 2024Trial
- A European Study of the Performance and Safety of MINIject in Patients With Medically Uncontrolled Open-angle Glaucoma (STAR-II).Journal of glaucoma · 2020Trial
- Visual Field Outcomes in the Tube Versus Trabeculectomy Study.Ophthalmology · 2020Trial
- Mitochondrial insufficiencies and neuroprotection in glaucoma.International ophthalmology · 2026Review
- Predicting worsening visual field via masked dual stage attention recurrent neural network.Scientific reports · 2026Article
- An Artificial Intelligence-Based Prognostic Model for Prediction of Functional Glaucoma Progression From Clinical and Structural Data.American journal of ophthalmology · 2026Article
- Is intraocular pressure the right criterion to assess progression or success in glaucoma?Indian journal of ophthalmology · 2026Article
- Phenotypic Heterogeneity in Glaucoma: The Systemic and Vascular Landscape Behind Functional Loss.Mediators of inflammation · 2026Observational
- Multimodal AI-based modeling of glaucoma progression: a 3PM-guided approach integrating structural, functional, and vascular patterns.The EPMA journal · 2025Article
- The Impact of Myopia on Regional Visual Field Loss and Progression in Glaucoma.Translational vision science & technology · 2025Article
- Applications of generative adversarial networks in the diagnosis, prognosis, and treatment of ophthalmic diseases.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Review
- Primary open-angle glaucoma: a perspective from plasma metabolomics.Expert review of molecular diagnostics · 2025Review
- High-Resolution Microperimetry for Detecting Glaucomatous Damage: A Prospective Evaluation of Performance.Clinical & experimental ophthalmology · 2025Article
- Repeatability of a Virtual Reality Headset Perimeter in Glaucoma and Ocular Hypertensive Patients.Translational vision science & technology · 2024Article
- Deep Learning Estimation of 10-2 Visual Field Map Based on Macular Optical Coherence Tomography Angiography Measurements.American journal of ophthalmology · 2024Article
- Bidirectional gated recurrent unit network model can generate future visual field with variable number of input elements.PloS one · 2024Article
- Phase I NT-501 Ciliary Neurotrophic Factor Implant Trial for Primary Open-Angle Glaucoma: Safety, Neuroprotection, and Neuroenhancement.Ophthalmology science · 2023Article
- Fast Progressors in Glaucoma: Prevalence Based on Global and Central Visual Field Loss.Ophthalmology · 2023Observational
- Risk factors for structural and functional progression of primary open-angle glaucoma in an African ancestry cohort.BMJ open ophthalmology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Clinically important rates of glaucoma progression (worsening) are ones that put a patient at risk of future functional impairment or reduction of vision-related quality of life. Rates of progression can be evaluated through measuring structural or functional changes of the optic nerve. Most treated eyes do not progress at rates that will lead to future visual impairment, but there are a significant proportion (3-17%) of eyes, that are at risk of impairment even under clinical care. While very fast rates of progression (e.g. MD progression of -1.5 dB/year) are generally problematic, much slower rates also may be deleterious for young patients, particularly those diagnosed with late disease. As a result, it is important to consider life expectancy, disease severity and vision-related quality of life based treatment targets to estimate future prognosis when evaluating whether a rate of glaucoma progression can be clinically relevant.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.