Evidence map›Paper›PMID 29657507›Full record

ArticleJournal of pharmacy & bioallied sciences

Initial Response of Human Bone Marrow-Derived Stem Cells after Contact with Ultrahigh-Molecular-Weight Polyethylene (UHMWPE) Material: An

Iwan B Anwar, Asep Santoso, Eko Saputra, Rifky Ismail, J Jamari, Emile van der Heide

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pharmacy & bioallied sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Iwan B AnwarOrthopaedic and Traumatology Department, Prof. Dr. R. Soeharso Orthopaedic Hospital, Surakarta, Indonesia.
Asep SantosoOrthopaedic and Traumatology Department, Prof. Dr. R. Soeharso Orthopaedic Hospital, Surakarta, Indonesia.
Eko SaputraLaboratory for Engineering Design and Tribology, Department of Mechanical Engineering, Diponegoro University, Tembalang, Semarang, Indonesia.
Rifky IsmailLaboratory for Engineering Design and Tribology, Department of Mechanical Engineering, Diponegoro University, Tembalang, Semarang, Indonesia.
J JamariLaboratory for Engineering Design and Tribology, Department of Mechanical Engineering, Diponegoro University, Tembalang, Semarang, Indonesia.
Emile van der HeideLaboratory for Surface Technology and Tribology, Faculty of Engineering Technology, University of Twente Drienerloolaan, Enschede, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionUltrahigh-molecular-weight polyethylene (UHMWPE) is a thermoplastic polymer useful in biomaterial applications, especially in orthopedic field. Yet, little is known concerning its initial effect on human bone marrow stem cells (hBMSCs) after implantation. MATERIALS AND

methodsA cytotoxicity analysis was performed with a 3-(4,5-dimethylthiazol 2-yl)-2,5-diphenyltetrazolium assay after 24, 48, and 72h of incubation of hBMSC culture. Expression of interleukin-6 (IL-6) was measured using enzyme-linked immunosorbent assay. Cell viability was measured with Inhibitory concentration 50% (IC

resultsAll treatment groups showed a cell viability of >50% ranging from 78% to >100%. Lower expression of IL-6 of hBMSC compared to control group was found in 48h of incubation period.

conclusionhBMSC showed high cell viability after initial contact with UHMWPE material. Modulation of IL-6 expression was present at the initial stage as a response to foreign material.

Indexed as

Cell viabilityhuman stem cellsinterleukin-6UHMWPE

Identifiers

PMID29657507
PMCPMC5887651

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.