ArticleJournal of orthopaedics2018
Assessment of the risk of low bone mineral density in premenopausal Japanese female patients with systemic lupus erythematosus.
Article in Journal of orthopaedics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Low BMI and postoperative outcomes in elderly hip fracture patients: a Japanese nationwide database study.Journal of bone and mineral metabolism · 2026Article
- Advancing osteoporosis diagnosis and fracture prediction: role of quantitative CT and future research directions.Archives of orthopaedic and trauma surgery · 2024Article
- Logistic Entropy of Trabecular Bone Score in SLE Patients and New Type Visualizations.Computational and mathematical methods in medicine · 2022Article
- Effect of denosumab switched from bisphosphonates in preventing joint destruction in postmenopausal rheumatoid arthritis patients with anti-cyclic citrullinated peptide antibodies.Journal of orthopaedic surgery and research · 2021Article
- Evaluation of risk factors of vertebral fracture in Japanese female patients with glucocorticoid-induced osteoporosis.Journal of orthopaedic surgery and research · 2020Article
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8 authors.
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Abstract
backgroundThe aim of this study was to assess the relationships between clinical parameters and bone mineral density (BMD) in Japanese female patients with systemic lupus erythematosus (SLE).
methodsA total of female 136 SLE patients without menopause were retrospectively assessed to identify associations between age, disease duration, body mass index (BMI), glucocorticoid usage and disease activity and BMD based on the treatment with or without bisphosphonate. There were 71 patients treated with bisphosphonate (bisphosphonate group) and 65 patients without (non-bisphosphonate group). We evaluated the impact of age, disease duration, BMI, serologic SLE markers, glucocorticoid use on BMD of the anterior-posterior (AP) and lateral lumbar spine, total hip and femoral neck using univariate and multivariate linear regression analyses of both bisphosphonate and non-bisphosphonate groups.
resultsMultivariate linear regression analyses showed that in non-bisphosphonate group disease duration was negatively associated with BMD of AP spine and femoral neck, whereas in bisphosphonate group these negative associations were not present. However, multivariate linear regression analyses showed a significant relationship between BMI and BMD of the AP spine, femoral neck and total hip, regardless of bisphosphonate treatment.
conclusionsBisphosphonate treatment eliminated the negative relationships between disease duration and the BMD of the spine and hip. AP spine and hip BMD in patients with SLE depend on BMI, regardless of bisphosphonate use. SLE serologic markers and glucocorticoid use were not negatively associated with generalized bone loss. SLE patients with low BMI have a high risk of generalized bone loss, and should be assessed and treated to prevent osteoporosis even before menopause.
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