Evidence map›Paper›PMID 29657300›Full record

ReviewNon-coding RNA2018

Besides Pathology: Long Non-Coding RNA in Cell and Tissue Homeostasis.

Amanda Salviano-Silva, Sara Cristina Lobo-Alves, Rodrigo Coutinho de Almeida, Danielle Malheiros, Maria Luiza Petzl-Erler

Open access · goldAbstract readReview
In one paragraph

Review in Non-coding RNA, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 1 pooled it
6.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 1 synthesis or guideline pooled it, 132 citations in OpenAlex.

  1. Pooled it
  2. Long noncoding RNAs in female malignancies: critical review of molecular mechanisms, clinical gaps, and therapeutic perspectives.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
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  9. Progress on long non-coding RNAs in calcific aortic valve disease.Frontiers in cardiovascular medicine · 2025
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17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Amanda Salviano-SilvaLaboratory of Human Molecular Genetics, Department of Genetics, Universidade Federal do Paraná, Curitiba 81531-980, Caixa Postal 19071, Brazil. amandasalviano92@gmail.com.
Sara Cristina Lobo-AlvesLaboratory of Human Molecular Genetics, Department of Genetics, Universidade Federal do Paraná, Curitiba 81531-980, Caixa Postal 19071, Brazil. saralobo5@yahoo.com.br.
Rodrigo Coutinho de AlmeidaLaboratory of Human Molecular Genetics, Department of Genetics, Universidade Federal do Paraná, Curitiba 81531-980, Caixa Postal 19071, Brazil. rodrigocout@gmail.com.
Danielle MalheirosLaboratory of Human Molecular Genetics, Department of Genetics, Universidade Federal do Paraná, Curitiba 81531-980, Caixa Postal 19071, Brazil. mfdani@yahoo.com.br.
Maria Luiza Petzl-ErlerLaboratory of Human Molecular Genetics, Department of Genetics, Universidade Federal do Paraná, Curitiba 81531-980, Caixa Postal 19071, Brazil. perler@ufpr.br.ORCID 0000-0002-0345-5276
Universidade Federal do Paraná · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A significant proportion of mammalian genomes corresponds to genes that transcribe long non-coding RNAs (lncRNAs). Throughout the last decade, the number of studies concerning the roles played by lncRNAs in different biological processes has increased considerably. This intense interest in lncRNAs has produced a major shift in our understanding of gene and genome regulation and structure. It became apparent that lncRNAs regulate gene expression through several mechanisms. These RNAs function as transcriptional or post-transcriptional regulators through binding to histone-modifying complexes, to DNA, to transcription factors and other DNA binding proteins, to RNA polymerase II, to mRNA, or through the modulation of microRNA or enzyme function. Often, the lncRNA transcription itself rather than the lncRNA product appears to be regulatory. In this review, we highlight studies identifying lncRNAs in the homeostasis of various cell and tissue types or demonstrating their effects in the expression of protein-coding or other non-coding RNA genes.

Indexed as

gene expressiongene regulationhomeostasislong non-coding RNAphysiological regulatory mechanismstranscriptome

Identifiers

PMID29657300
PMCPMC5890390
OpenAlexW2788738593

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.