ArticleJournal of clinical and experimental hematopathology : JCEH2018
Colonal monomorphic epitheliotropic intestinal T-cell lymphoma with novel phenotype of cytoplasmic CD3 expression.
Article in Journal of clinical and experimental hematopathology : JCEH, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 13 citations in OpenAlex.
- Multiple Elective Surgeries and Cord Blood Transplantation for Multi-refractory Monomorphic Epitheliotropic Intestinal T-cell Lymphoma.Internal medicine (Tokyo, Japan) · 2026Article
- Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma: A Case of Extranodal Non-Hodgkin Lymphoma in the Jejunum with Invasion of the Abdominal Wall and Transverse Colon.Surgical case reports · 2026Article
- Article
- Surgical management of monomorphic epitheliotropic intestinal T-cell lymphoma followed by chemotherapy and stem-cell transplant: A case report and review of the literature.World journal of gastrointestinal oncology · 2022Article
- Surface CD3-negative monomorphic epitheliotropic intestinal T-cell lymphoma.Journal of clinical and experimental hematopathology : JCEH · 2022Article
- Endoscopic and clinicopathological characteristics of colorectal T/NK cell lymphoma.Diagnostic pathology · 2020Article
- Monomorphic Epitheliotropic Intestinal T Cell Lymphoma of the Appendix: a Case Report and Review of Literature.Journal of gastrointestinal cancer · 2020Review
- Truth lies below: A case report and literature review of typical appearing polyps yet with an atypical diagnosis.World journal of gastrointestinal endoscopy · 2019Article
- Various Endoscopic Features in Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma.Case reports in gastroenterologyArticle
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Authors and funding
8 authors at 1 institution in 1 country.
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Abstract
Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is a new clinical entity that was reclassified from enteropathy-associated T-cell lymphoma in the 2016 WHO classification. An 83-year-old man with fever and diarrhea was referred to our hospital because of free air in the abdominal cavity and wall thickening of the large intestine on CT. Colonofiberscopic examination revealed mucosal edema and multiple ulcers at the sigmoid colon, splenic flexure, and transverse colon. Histopathological examination of the mucosal biopsy specimen demonstrated dense infiltration of small lymphocytes with nuclear atypia, some of which exhibited intraepithelial invasion. Immunohistologically, these lymphocytes were positive for CD3, CD56, and perforin. Regarding CD3 expression, the antigen was found to only be expressed in the cytoplasm and not on the surface membrane on flow cytometric analysis. PCR examination of the T-cell receptor (TCR) gene revealed monoclonal gene rearrangements of TCR-γ and TCR-β. Based on these findings, a diagnosis of colonal MEITL with cyCD3 expression at Lugano clinical stage 1 was made. After conservative management of the peritonitis, we treated the patient with CHOP and DeVIC regimens, but he developed progressive disease and died. The cyCD3 expression in MEITL may be novel, suggesting a thymocyte origin of the tumor cells.
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