Evidence map›Paper›PMID 29657232›Full record

ArticleThe Journal of reproduction and development2018

CRISPR/Cas9-mediated knock-in of the murine Y chromosomal Sry gene.

Kenya Imaimatsu, Wataru Fujii, Ryuji Hiramatsu, Kento Miura, Masamichi Kurohmaru, Yoshiakira Kanai

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of reproduction and development, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Generation of Flag/DYKDDDDK Epitope Tag Knock-In Mice UsingInternational journal of molecular sciences · 2022
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Kenya ImaimatsuDepartment of Veterinary Anatomy, The University of Tokyo, Tokyo 113-8657, Japan.
Wataru FujiiDepartment of Animal Resource Sciences, The University of Tokyo, Tokyo 113-8657, Japan.
Ryuji HiramatsuDepartment of Veterinary Anatomy, The University of Tokyo, Tokyo 113-8657, Japan.
Kento MiuraDepartment of Veterinary Anatomy, The University of Tokyo, Tokyo 113-8657, Japan.
Masamichi KurohmaruDepartment of Veterinary Anatomy, The University of Tokyo, Tokyo 113-8657, Japan.
Yoshiakira KanaiDepartment of Veterinary Anatomy, The University of Tokyo, Tokyo 113-8657, Japan.
The University of Tokyo · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mammalian zygote-mediated genome editing via the clustered regularly interspaced short palindromic repeats/CRISPR-associated endonuclease 9 (CRISPR/Cas9) system is widely used to generate genome-modified animals. This system allows for the production of loss-of-function mutations in various Y chromosome genes, including Sry, in mice. Here, we report the establishment of a CRISPR-Cas9-mediated knock-in line of Flag-tag sequences into the Sry locus at the C-terminal coding end of the Y chromosome (Y

Indexed as

CRISPR-Cas SystemsGenes, sryAnimalsGene EditingMaleMiceSex-Determining Region Y ProteinTestisSex-Determining Region Y ProteinSry protein, mouseCRISPR/Cas9SRYSRY-FlagTestisY chromosome

Identifiers

PMID29657232
PMCPMC6021606
OpenAlexW2809875178

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.