ArticleThe Journal of veterinary medical science2018
Tunnel use facilitates handling of ICR mice and decreases experimental variation.
Article in The Journal of veterinary medical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 42 citations in OpenAlex.
- Developmental molecular signatures define de novo cortico-brainstem circuit for skilled forelimb movement.Nature communications · 2026Article
- Enhancing Rodent Welfare, Cost Savings, and Efficiency: Implementation and Review of Data-Driven Improvements.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Review
- Effects of Scruff Restraint and Handling-Tail and Tunnel-on Plasma Corticosterone in Female BALB/c Mice (Mus musculus).Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Article
- Lack of evidence for a consistent differential impact of tail and tunnel handling on markers of welfare in laboratory mice.Scientific reports · 2025Article
- The effects of handling on mouse behavior: cupped hands versus familiar or novel huts or tunnels.PloS one · 2025Article
- The implementation of tunnel handling in a mouse breeding facility revealed strain-specific behavioural responses.Laboratory animals · 2024Article
- Design and validation of novel flow cytometry panels to analyze a comprehensive range of peripheral immune cells in mice.Frontiers in immunology · 2024Article
- Using refined methods to pick up mice: A survey benchmarking prevalence & beliefs about tunnel and cup handling.PloS one · 2023Article
- An investigation of the perceptions of laboratory animal welfare issues among undergraduate and graduate veterinary students in southeastern China.Frontiers in veterinary science · 2023Article
- Decreased levels of discomfort in repeatedly handled mice during experimental procedures, assessed by facial expressions.Frontiers in behavioral neuroscience · 2023Article
- Handling method affects measures of anxiety, but not chronic stress in mice.Scientific reports · 2022Article
- Effects of a Multimodal Approach Using Buprenorphine with/without Meloxicam on Food Intake, Body Weight, Nest Consolidating Behavior, Burrowing Behavior, and Gastrointestinal Tissues in Postoperative Male Mice.Veterinary sciences · 2022Article
- Impact of Refinements to Handling and Restraint Methods in Mice.Animals : an open access journal from MDPI · 2022Article
- Assessment of the Safety and Efficacy of Pre-emptive Use of Extended-release Buprenorphine for Mouse Laparotomy.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- Non-Invasive Assessment of Mild Stress-Induced Hyperthermia by Infrared Thermography in Laboratory Mice.Animals : an open access journal from MDPI · 2022Article
- Use of nonaversive handling and training procedures for laboratory mice and rats: Attitudes of American and Canadian laboratory animal professionals.Frontiers in veterinary science · 2022Article
- Effects of non-aversive versus tail-lift handling on breeding productivity in a C57BL/6J mouse colony.PloS one · 2022Article
- Welfare Assessment, End-Point Refinement and the Effects of Non-Aversive Handling in C57BL/6 Mice with Lewis Lung Cancer.Animals : an open access journal from MDPI · 2021Article
- Increased MMP-9 levels with strain-dependent stress resilience and tunnel handling in mice.Behavioural brain research · 2021Article
- Influence of acute exposure to a low dose of systemic insecticide fipronil on locomotor activity and emotional behavior in adult male mice.The Journal of veterinary medical science · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We evaluated a handling method using tunnels to tame laboratory mice (ICR) in the context of animal welfare and ease of handling. During 1-week acclimation to handling and subsequent 1-week oral administration (once per day), voluntary interaction with the experimenter was much greater in mice handled by a tunnel compared to those picked up by the tail. According to a rating of the ease of handling laboratory mice, a tunnel facilitated mouse handling during acclimation to handling and oral gavage of saline compared to tail handling. In addition, mice handled by a tunnel showed less anxiety than mice handled by the tail in the open field test, but not in elevated plus maze. Calculation of experimental variation in behavioral tests, which were used to mimic pharmacological studies, suggested that mice handled by a tunnel exhibited the tendency of less variation compared to those picked up by the tail, in both groups that were intraperitoneally administered saline as placebo and diazepam as an active drug. Thus, tunnel use could be beneficial for improving animal welfare and facilitated handling of ICR mice in mouse studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.