ArticleCurrent biology : CB2018
Functional Maps of Mechanosensory Features in the Drosophila Brain.
Article in Current biology : CB, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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Who cites it
63 citing papers in PubMed.
- Article
- Antennal Lobe Dynamics And The Generation Of Diverse Response Patterns To Mechanosensory Stimulation.bioRxiv : the preprint server for biology · 2026Article
- Article
- Sensory-motor integration in a nonspiking interneuron contributes to active sensor control inbioRxiv : the preprint server for biology · 2026Article
- Multisensory integration for active mechanosensation in Drosophila flight.Current biology : CB · 2026Article
- Article
- A method for mechanically blocking antennal joints in Drosophila.The Journal of experimental biology · 2025Article
- Chemosensation drives divergent social behavior in Drosophila.Communications biology · 2025Article
- Sexual dimorphism in the complete connectome of thebioRxiv : the preprint server for biology · 2025Article
- Disinhibition of a recurrent attractor gates a persistent goal signal for navigation.bioRxiv : the preprint server for biology · 2025Article
- Article
- Sexually-dimorphic neurons in theResearch square · 2025Article
- Multisensory integration for active mechanosensation inbioRxiv : the preprint server for biology · 2025Article
- Sexually-dimorphic neurons in thebioRxiv : the preprint server for biology · 2025Article
- Diversity and complexity of auditory representation in the hearing systems ofScience advances · 2025Article
- Inferring neural population codes forProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Divergent neural circuits for proprioceptive and exteroceptive sensing of the Drosophila leg.Nature communications · 2025Article
- Encoding of antennal position and velocity by the Johnston's organ in hawkmoths.The Journal of experimental biology · 2025Article
- Emergence of a brainstem somatosensory tonotopic map for substrate vibration.Nature neuroscience · 2025Article
- From bristle to brain: embryonic development of topographic projections from basiconic sensilla in the antennal nervous system of the locust Schistocerca gregaria.Development genes and evolution · 2024Article
3 more citing papers are in PubMed but not listed here.
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2 authors.
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Abstract
Johnston's organ is the largest mechanosensory organ in Drosophila. It contributes to hearing, touch, vestibular sensing, proprioception, and wind sensing. In this study, we used in vivo 2-photon calcium imaging and unsupervised image segmentation to map the tuning properties of Johnston's organ neurons (JONs) at the site where their axons enter the brain. We then applied the same methodology to study two key brain regions that process signals from JONs: the antennal mechanosensory and motor center (AMMC) and the wedge, which is downstream of the AMMC. First, we identified a diversity of JON response types that tile frequency space and form a rough tonotopic map. Some JON response types are direction selective; others are specialized to encode amplitude modulations over a specific range (dynamic range fractionation). Next, we discovered that both the AMMC and the wedge contain a tonotopic map, with a significant increase in tonotopy-and a narrowing of frequency tuning-at the level of the wedge. Whereas the AMMC tonotopic map is unilateral, the wedge tonotopic map is bilateral. Finally, we identified a subregion of the AMMC/wedge that responds preferentially to the coherent rotation of the two mechanical organs in the same angular direction, indicative of oriented steady air flow (directional wind). Together, these maps reveal the broad organization of the primary and secondary mechanosensory regions of the brain. They provide a framework for future efforts to identify the specific cell types and mechanisms that underlie the hierarchical re-mapping of mechanosensory information in this system.
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