Evidence map›Paper›PMID 29657092›Full record

ArticleBiomaterials2018

The critical chemical and mechanical regulation of folic acid on neural engineering.

Gloria B Kim, Yongjie Chen, Weibo Kang, Jinshan Guo, Russell Payne, Hui Li, Qiong Wei, Julianne Baker, Cheng Dong, Sulin Zhang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. WNT4 reprograms dental pulp stem cells to resist PANoptosis and rebuild neurogenic potential for facial nerve injury repair.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Article
  3. Article
  4. Article
  5. [Research progress of silk-based biomaterials for peripheral nerve regeneration].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2024
    Review
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  8. Article
  9. Review
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  12. [Effect of folic acid coated-crosslinked urethane-doped polyester elastomer nerve conduit on promoting the repair of long distance peripheral nerve injury in rats].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2023
    Article
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  14. Review
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  18. Article
  19. Article
  20. Mechanosensing by Gli1Cell proliferation · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Gloria B KimDepartment of Biomedical Engineering, Materials Research Institute, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
Yongjie ChenDepartment of Orthopedic Surgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, PR China.
Weibo KangDepartment of Orthopedic Surgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, PR China.
Jinshan GuoDepartment of Biomedical Engineering, Materials Research Institute, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
Russell PayneDepartment of Neurosurgery, Penn State Milton S. Hershey Medical Center, Hershey, PA 17033, USA.
Hui LiDepartment of Biomedical Engineering, Materials Research Institute, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
Qiong WeiDepartment of Engineering Science and Mechanics, Materials Research Institute, The Pennsylvania State University, University Park, PA 16802, USA.
Julianne BakerDepartment of Biomedical Engineering, Materials Research Institute, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
Cheng DongDepartment of Biomedical Engineering, Materials Research Institute, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
Sulin ZhangDepartment of Neurosurgery, Penn State Milton S. Hershey Medical Center, Hershey, PA 17033, USA.
Pak Kin WongDepartment of Biomedical Engineering, Materials Research Institute, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
Elias B RizkDepartment of Neurosurgery, Penn State Milton S. Hershey Medical Center, Hershey, PA 17033, USA.
Jiazhi YanDepartment of Orthopedic Surgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, PR China. Electronic address: beijingtiantan@163.com.
Jian YangDepartment of Biomedical Engineering, Materials Research Institute, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA. Electronic address: jxy30@psu.edu.
Pennsylvania State University · USPenn State Milton S. Hershey Medical Center · USCapital Medical University · CNBeijing Tian Tan Hospital · CN

Funding

Developing targeted therapy with prostate cancer specific nanomedicineR01CA182670 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI HSIEH, JER-TSONG, YANG, JIAN · 2013 to 2017
$1.6M
Novel Engineered Particle Platform for Endothelium RegenerationR01HL118498 · NHLBI · UNIVERSITY OF TEXAS ARLINGTON · PI NGUYEN, KYTAI TRUONG, YANG, JIAN · 2014 to 2017
$1.5M
NCI NIH HHS R01 CA182670NHLBI NIH HHS R01 HL118498
6 · The paper itself

Abstract

The mandate of folic acid supplementation in grained products has reduced the occurrence of neural tube defects by one third in the U.S since its introduction by the Food and Drug Administration in 1998. However, the advantages and possible mechanisms of action of using folic acid for peripheral nerve engineering and neurological diseases still remain largely elusive. Herein, folic acid is described as an inexpensive and multifunctional niche component that modulates behaviors in different cells in the nervous system. The multiple benefits of modulation include: 1) generating chemotactic responses on glial cells, 2) inducing neurotrophin release, and 3) stimulating neuronal differentiation of a PC-12 cell system. For the first time, folic acid is also shown to enhance cellular force generation and global methylation in the PC-12 cells, thereby enabling both biomechanical and biochemical pathways to regulate neuron differentiation. These findings are evaluated in vivo for clinical translation. Our results suggest that folic acid-nerve guidance conduits may offer significant benefits as a low-cost, off-the-shelf product for reaching the functional recovery seen with autografts in large sciatic nerve defects. Consequently, folic acid holds great potential as a critical and convenient therapeutic intervention for neural engineering, regenerative medicine, medical prosthetics, and drug delivery.

Indexed as

AnimalsAstrocytesCell DifferentiationCell ProliferationCell SurvivalChemotaxisDNA MethylationFolic AcidHumansMaleMicrotubule-Associated ProteinsNerve Growth FactorsNervous SystemNeuritesPC12 CellsPolyestersFolic AcidMAP2 protein, ratMicrotubule-Associated ProteinsNerve Growth FactorsPolyestersFolic acidMedical prostheticsNeural engineeringRegenerative medicine

Identifiers

PMID29657092
PMCPMC6328061
OpenAlexW2804159257

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.