Evidence map›Paper›PMID 29657091›Full record

ArticleBiomaterials2018

Injectable polypeptide hydrogels via methionine modification for neural stem cell delivery.

A L Wollenberg, T M O'Shea, J H Kim, A Czechanski, L G Reinholdt, M V Sofroniew, T J Deming

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
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  3. Triggered Inversion of Dual Responsive Diblock Copolypeptide Vesicles.Journal of the American Chemical Society · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

A L WollenbergDepartments of Bioengineering, Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095-1600, USA.
T M O'SheaDepartment of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1763, USA.
J H KimDepartment of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1763, USA.
A CzechanskiThe Jackson Laboratory, Bar Harbor, ME 04609, USA.
L G ReinholdtThe Jackson Laboratory, Bar Harbor, ME 04609, USA.
M V SofroniewDepartment of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1763, USA.
T J DemingDepartments of Bioengineering, Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095-1600, USA. Electronic address: demingt@seas.ucla.edu.
University of California, Los Angeles · USJackson Laboratory · US

Funding

Injectable biomaterial depots to manipulate scar and foster axon growth after SCIR01NS084030 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SOFRONIEW, MICHAEL V · 2014 to 2023
$3.0M
Topical Microbicides: Targeted Intracellular DeliveryR01AI112016 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ANTON, PETER A, YANG, OTTO O · 2014 to 2017
$2.3M
NIAID NIH HHS R01 AI112016NINDS NIH HHS R01 NS084030
6 · The paper itself

Abstract

Injectable hydrogels with tunable physiochemical and biological properties are potential tools for improving neural stem/progenitor cell (NSPC) transplantation to treat central nervous system (CNS) injury and disease. Here, we developed injectable diblock copolypeptide hydrogels (DCH) for NSPC transplantation that contain hydrophilic segments of modified l-methionine (Met). Multiple Met-based DCH were fabricated by post-polymerization modification of Met to various functional derivatives, and incorporation of different amino acid comonomers into hydrophilic segments. Met-based DCH assembled into self-healing hydrogels with concentration and composition dependent mechanical properties. Mechanical properties of non-ionic Met-sulfoxide formulations (DCH

Indexed as

InjectionsStem Cell TransplantationAnimalsAstrocytesBiomarkersBrainCationsCell AdhesionCell DifferentiationCell LineCell SurvivalHydrogelsMethionineMice, Inbred C57BLNeural Stem CellsNeuronsBiomarkersCationsHydrogelsMethioninePeptidesSafrolesulfoxideBiomaterialsBrainCell transplantationHydrogelsNeural stem cellsPolypeptides

Identifiers

PMID29657091
PMCPMC6054810
OpenAlexW2796153157

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.