ArticleDevelopmental cell2018
Synaptotagmin 4 Regulates Pancreatic β Cell Maturation by Modulating the Ca
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Article in Developmental cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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60citing papers in PubMed
11.8field-weighted citation impact, top 1% of its field
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60 citing papers in PubMed, 101 citations in OpenAlex.
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- Latent plasticity of the human pancreas across development, health, and disease.bioRxiv : the preprint server for biology · 2025Article
- An Examination of Sirolimus's Role in Endothelial Cells of Kaposiform Haemangioendothelioma.Journal of cellular and molecular medicine · 2025Article
- Pancreatic islet β-cell subtypes are derived from biochemically-distinct and nutritionally-regulated islet progenitors.Nature communications · 2025Article
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- Electrophysiological Characterization of Inducible Pluripotent Stem Cell-Derived Human β-Like Cells and an SLC30A8 Disease Model.Diabetes · 2024Article
- Synaptotagmins family affect glucose transport in retinal pigment epithelial cells through their ubiquitination-mediated degradation and glucose transporter-1 regulation.World journal of diabetes · 2024Article
- Amlodipine inhibits Synaptotagmin-4's oncogenic activity on gastric cancer proliferation by targeting calcium signaling.Functional & integrative genomics · 2024Article
- Adjudin improves beta cell maturation, hepatic glucose uptake and glucose homeostasis.Diabetologia · 2024Article
- Stem Cell Therapy for the Management of Type 1 Diabetes: Advances and Perspectives.Endocrine, metabolic & immune disorders drug targets · 2024Review
- Rab26 restricts insulin secretion via sequestering Synaptotagmin-1.PLoS biology · 2023Article
- Cholesterol Redistribution in Pancreatic β-Cells: A Flexible Path to Regulate Insulin Secretion.Biomolecules · 2023Review
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Authors and funding
20 authors at 6 institutions in 3 countries.
Chen HuangDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA; Center for Stem Cell Biology, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA; The Program of Developmental Biology, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA.
Emily M WalkerDepartment of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA.
Prasanna K DadiDepartment of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA.
Ruiying HuDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA; Center for Stem Cell Biology, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA; The Program of Developmental Biology, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA.
Yanwen XuDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA; Center for Stem Cell Biology, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA; The Program of Developmental Biology, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA.
Wenjian ZhangChina-Japan Friendship Hospital, Beijing 100029, P. R. China.
Tiziana SanaviaDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.
Jisoo MunDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA.
Jennifer LiuDiabetes Center, UCSF, San Francisco, CA 94143, USA.
Gopika G NairDiabetes Center, UCSF, San Francisco, CA 94143, USA.
Hwee Yim Angeline TanLaboratory of Metabolic Medicine, Singapore Bioimaging Consortium, Singapore, Singapore.
Sui WangDepartment of Ophthalmology, Mary M. and Sash A. Spencer Center for Vision Research, Stanford University School of Medicine, Palo Alto, CA 94304, USA.
Mark A MagnusonDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA; Center for Stem Cell Biology, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA.
Christian J StoeckertInstitute for Biomedical Informatics and Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
Matthias HebrokDiabetes Center, UCSF, San Francisco, CA 94143, USA.
Maureen GannonDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA; Center for Stem Cell Biology, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA; The Program of Developmental Biology, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA; Department of Medicine, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA.
Weiping HanLaboratory of Metabolic Medicine, Singapore Bioimaging Consortium, Singapore, Singapore.
Roland SteinDepartment of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA.
David A JacobsonDepartment of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA. Electronic address: david.a.jacobson@vanderbilt.edu.
Guoqiang GuDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA; Center for Stem Cell Biology, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA; The Program of Developmental Biology, Vanderbilt University School of Medicine, Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37232, USA. Electronic address: guoqiang.gu@vanderbilt.edu.
Tennessee Valley Authority · USSingapore Bioimaging Consortium · SGChina-Japan Friendship Hospital · CNHarvard University · USStanford University · USUniversity of Pennsylvania · US
Funding
Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STACIE B DUSETZINA · 1995 to 2026
$172.8MVIRAL VECTOR COREP30DK019525 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Patrick Seale · 1986 to 2026
$48.3MTranslational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9MVanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ALVIN C POWERS · 2012 to 2026
$29.3MTRANSGENIC MOUSE/ ES CELL SHARES RESOURCESP60DK020593 · NIDDK · VANDERBILT UNIVERSITY · PI POWERS, ALVIN C · 1986 to 2011
$28.1MShop Module CoreP30EY008126 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI David J. Calkins · 1989 to 2026
$19.6MVanderbilt Mouse Metabolic Physiology CenterU24DK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2001 to 2015
$14.9MPDX-1,A TRANSCRIPTIONAL ACTIVATOR OF THE INSULIN GENER01DK050203 · NIDDK · VANDERBILT UNIVERSITY · PI BASS, JOSEPH, STEIN, ROLAND W · 1995 to 2020
$6.8MMicrotubule Regulation of Pancreatic Beta Cell Function and DiabetesR01DK106228 · NIDDK · VANDERBILT UNIVERSITY · PI Guoqiang Gu, William Holmes · 2016 to 2026
$6.4MDefining the Role of MafA in Islet Beta CellsR01DK090570 · NIDDK · VANDERBILT UNIVERSITY · PI PARENT, AUDREY, STEIN, ROLAND W · 2011 to 2025
$5.9MGenetic control of pancreatic endocrine cell developmentU01DK089523 · NIDDK · VANDERBILT UNIVERSITY · PI MAGNUSON, MARK A · 2010 to 2014
$5.3MThe Mechanisms of Islet Cell Specification and DifferentiationR01DK065949 · NIDDK · VANDERBILT UNIVERSITY · PI GU, GUOQIANG · 2004 to 2017
$4.4MNCI NIH HHS P30 CA068485NEI NIH HHS P30 EY008126NIDDK NIH HHS P30 DK019525NIDDK NIH HHS P30 DK020593NIDDK NIH HHS P30 DK058404NIDDK NIH HHS R01 DK050203NIDDK NIH HHS R01 DK065949NIDDK NIH HHS R01 DK090570NIDDK NIH HHS R01 DK097392NIDDK NIH HHS R01 DK105831NIDDK NIH HHS R01 DK106228NIDDK NIH HHS R01 DK108666NIDDK NIH HHS R01 DK115620NIDDK NIH HHS R01 DK125696NIDDK NIH HHS U01 DK089523NIDDK NIH HHS U24 DK059637
Abstract
Islet β cells from newborn mammals exhibit high basal insulin secretion and poor glucose-stimulated insulin secretion (GSIS). Here we show that β cells of newborns secrete more insulin than adults in response to similar intracellular Ca
Indexed as
AnimalsBiological TransportCalciumCell DifferentiationFemaleGene Expression RegulationGlucoseHumansHypoglycemic AgentsInsulinInsulin-Secreting CellsInsulin SecretionMaleMiceMice, KnockoutSweetening AgentsCalciumGlucoseHypoglycemic AgentsInsulinSweetening AgentsSynaptotagminsCa(2+)diabetesdockinginsulinmaturationmembrane fusionMyt1secretionSyt4vesicle
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