ArticleNeuron2018
The Medial Prefrontal Cortex Shapes Dopamine Reward Prediction Errors under State Uncertainty.
Article in Neuron, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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Who cites it
83 citing papers in PubMed.
- Top-down control of sustained attention by medial prefrontal cortex-locus coeruleus (mPFC-LC) projection neurons during the rodent continuous performance test (rCPT).Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Decoding behavior with minimal and interpretable agent models.PLoS computational biology · 2026Article
- Task-dependent neural dynamics in hippocampal CA1 during auditory and visual perceptual decision-making in rats.Brain structure & function · 2026Article
- Learning to select computations in recurrent neural circuits.bioRxiv : the preprint server for biology · 2026Article
- A bio-inspired minimal model for non-stationary K-armed bandits.Biological cybernetics · 2026Article
- Uncertainty and reward histories have distinct effects on decisions after wins and losses.Scientific reports · 2026Article
- Disrupted synapses: prefrontal cortex-reward circuit dysfunction in stress-induced depression-like behaviors.Frontiers in cellular neuroscience · 2026Review
- Top-down control of sustained attention by the medial prefrontal cortex (mPFC) - locus coeruleus (LC) circuit during the rodent continuous performance test (rCPT).bioRxiv : the preprint server for biology · 2025Article
- Patterns of neural activity in prelimbic cortex neurons correlate with attentional behavior in the rodent continuous performance test.Translational psychiatry · 2025Article
- Habenula-ventral tegmental area functional coupling and risk aversion in humans.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Neural variability in the default mode network compresses with increasing belief precision during Bayesian inference.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Patterns of neural activity in prelimbic cortex neurons correlate with attentional behavior in the rodent continuous performance test.bioRxiv : the preprint server for biology · 2025Article
- 20 Years of Aberrant Salience in Psychosis: What Have We Learned?The American journal of psychiatry · 2025Review
- Striatal Gradient in Value-Decay Explains Regional Differences in Dopamine Patterns and Reinforcement Learning Computations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Executive dysfunction is associated with altered hippocampal-prefrontal functional connectivity in 3xTg Alzheimer's model mice.Communications biology · 2025Article
- Neural mechanisms of confidence propagation in hierarchical partially observable decision-making.iScience · 2025Article
- Article
- Prospective contingency explains behavior and dopamine signals during associative learning.Nature neuroscience · 2025Article
- Frontal noradrenergic and cholinergic transients exhibit distinct spatiotemporal dynamics during competitive decision-making.Science advances · 2025Article
23 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors.
Funding
Abstract
Animals make predictions based on currently available information. In natural settings, sensory cues may not reveal complete information, requiring the animal to infer the "hidden state" of the environment. The brain structures important in hidden state inference remain unknown. A previous study showed that midbrain dopamine neurons exhibit distinct response patterns depending on whether reward is delivered in 100% (task 1) or 90% of trials (task 2) in a classical conditioning task. Here we found that inactivation of the medial prefrontal cortex (mPFC) affected dopaminergic signaling in task 2, in which the hidden state must be inferred ("will reward come or not?"), but not in task 1, where the state was known with certainty. Computational modeling suggests that the effects of inactivation are best explained by a circuit in which the mPFC conveys inference over hidden states to the dopamine system. VIDEO ABSTRACT.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.