Evidence map›Paper›PMID 29656871›Full record

ArticleNeuron2018

Activation of G

Rachel N Arey, Geneva M Stein, Rachel Kaletsky, Amanda Kauffman, Coleen T Murphy

Open access · bronzeAbstract read
In one paragraph

Article in Neuron, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
1.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 56 citations in OpenAlex.

  1. Article
  2. AlteredeNeuro · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. AlteredbioRxiv : the preprint server for biology · 2025
    Article
  11. Article
  12. Genes & development · 2025
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Neuronal activation of GCell reports · 2023
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Rachel N AreyLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA; Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Geneva M SteinLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA; Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Rachel KaletskyLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA; Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Amanda KauffmanLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA; Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Coleen T MurphyLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA; Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA. Electronic address: ctmurphy@princeton.edu.
Princeton University · US

Funding

Molecular Mechanisms Regulating Age-Related Cognitive Decline in C. elegansR01AG034446 · NIA · PRINCETON UNIVERSITY · PI MURPHY, COLEEN TARA · 2009 to 2019
$3.1M
Identifying postsynaptic regulators of long-term memory in Caenorhabditis elegansF32AG046106 · NIA · PRINCETON UNIVERSITY · PI AREY, RACHEL NICOLE · 2014 to 2017
$167k
NIA NIH HHS F32 AG046106NIA NIH HHS R01 AG034446
6 · The paper itself

Abstract

Perhaps the most devastating decline with age is the loss of memory. Therefore, identifying mechanisms to restore memory function with age is critical. Using C. elegans associative learning and memory assays, we identified a gain-of-function G

Indexed as

AnimalsAnimals, Genetically ModifiedCaenorhabditis elegansCognitive DysfunctionCyclic AMP Response Element-Binding ProteinGTP-Binding Protein alpha Subunits, Gq-G11Memory ConsolidationSignal TransductionCyclic AMP Response Element-Binding ProteinGTP-Binding Protein alpha Subunits, Gq-G11

Identifiers

PMID29656871
PMCPMC5934306
OpenAlexW2797508799

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.