ReviewPresse medicale (Paris, France : 1983)2018
Impact on the brain of the inflammatory response to surgery.
Review in Presse medicale (Paris, France : 1983), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05474872 (Postoperative Delirium), which is not on this map. Cited by 55 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Postoperative Delirium: a Complex Prediction Model in Patients Undergoing Major Abdominal Surgery
Who cites it
55 citing papers in PubMed, 2 syntheses or guidelines pooled it, 94 citations in OpenAlex.
- Effects of neostigmine on postoperative neurocognitive dysfunction: a systematic review and meta-analysis.Frontiers in neuroscience · 2025Pooled it
- Pooled it
- Safety of intranasal insulin administration in patients undergoing cardiovascular surgery: An open-label, nonrandomized, dose-escalation study.JTCVS open · 2024Trial
- Voluntary wheel running behavior is reduced by SARS-CoV-2 S1 administration and mitigates hypothalamic neuroinflammatory processes.Brain, behavior, & immunity - health · 2026Article
- A comparison of large language model-generated and published perioperative neurocognitive disorder recommendations: a cross-sectional web-based analysis.British journal of anaesthesia · 2026Article
- Effect of preoperative intranasal insulin on postoperative delirium in adult surgical patients: a systematic review, meta-analysis, and trial sequential analysis.Perioperative medicine (London, England) · 2026Article
- Operationalizing perioperative clearance reserve: a reserve-load interaction model for neurocognitive outcomes in older surgical patients.Frontiers in medicine · 2026Article
- Inflammatory mechanisms contribute to long-term cognitive deficits induced by perinatal asphyxia via interleukin-1.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Resveratrol attenuates LPS-induced oxidative stress and apoptosis in HMC3 microglial cells, partly involving NRF2-related signaling.American journal of translational research · 2026Article
- Methylene blue reduces postoperative delirium in mice through neuroinflammation suppression and blood-brain barrier repair.Scientific reports · 2025Article
- Nicotinamide Prevents the Plasticity Impairments and the Cognitive Dysfunction Caused by Bone Fracture in Older Mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Evaluating patient knowledge about peri-operative neurocognitive disorders (KNOW-PND study): A feasibility study.European journal of anaesthesiology and intensive care · 2025Article
- Role of gut microbiota in neuroinflammation: a focus on perioperative neurocognitive disorders.Frontiers in cellular and infection microbiology · 2025Review
- Viral immunological complications in neurological surgery: A comprehensive review of homeostatic disturbances and cognitive impairments.Surgical neurology international · 2025Review
- Circulating tsRNAs serve as potential biomarkers for predicting postoperative delirium in elderly patients receiving lower extremity orthopedic surgery.Frontiers in psychiatry · 2025Article
- Linear association between high-sensitivity C-reactive protein and postoperative delirium after general anesthesia: a cross-sectional study.Frontiers in neurology · 2025Article
- Emerging biomarkers of postoperative delirium at the intersection of neuroinflammation and neurodegeneration.Frontiers in aging neuroscience · 2025Review
- Relevance of Preoperative Cognitive Impairment for Predicting Postoperative Delirium in Surgical Medicine: A Prospective Cohort Study.Geriatrics (Basel, Switzerland) · 2024Article
- Subjective Cognitive Complaints and Anecdotal Descriptions of Postoperative Cognitive Decline: Missing Pieces of the Postoperative Neurocognitive Disorder Puzzle.Advances in anesthesia · 2024Review
- Microglia mediate memory dysfunction via excitatory synaptic elimination in a fracture surgery mouse model.Journal of neuroinflammation · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The brain is both the orchestrator as well as the target of the innate immune system's response to the aseptic trauma of surgery. When trauma-induced inflammation is not appropriately regulated persistent neuro-inflammation interferes with the synaptic plasticity that underlies the learning and memory aspects of cognition. The complications that ensue, include postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) at two poles of a constellation that is now termed perioperative neurocognitive disorders. While the relationship of acute POD to the more indolent POCD is not completely understood both can be further complicated by earlier-onset of dementia and higher mortality. How and why these disorders occur is the focus of this report. The innate immune system response to peripheral trauma signals to the brain through a regulated cascade of cellular and molecular actors producing a teleological defense mechanism, "sickness behavior," to curtail further injury and initiate repair. Sickness behavior, including disordered cognition, is terminated by neural and humoral pathways that restore homeostasis and launch the organism on a path to good health. With so many "moving parts" the innate immune system is vulnerable in clinical settings that include advanced age and lifestyle-induced diseases such as "unhealthy" obesity and the inevitable insulin resistance. Under these conditions, inflammation may become exaggerated and long-lived. Consideration is provided how to identify the high-risk surgical patient and both pharmacological (including biological compounds) and non-pharmacological strategies to customize care.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.