Evidence map›Paper›PMID 29656398›Full record

ArticleClinical transplantation2018

Impact of prolonged dialysis prior to renal transplantation.

David D Aufhauser, Allison W Peng, Douglas R Murken, Seth J Concors, Peter L Abt, Deirdre Sawinski, Roy D Bloom, Peter P Reese, Matthew H Levine

Abstract read
In one paragraph

Article in Clinical transplantation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Short Pretransplant Dialysis Periods are Clinically Acceptable Without Compromising Kidney Transplant Outcomes: A Japanese Multicenter Study.International journal of urology : official journal of the Japanese Urological Association · 2026
    Article
  2. Population-Specific Exploration ofInternational journal of molecular sciences · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

David D AufhauserDepartment of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.ORCID 0000-0001-9028-6046
Allison W PengDepartment of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Douglas R MurkenDepartment of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Seth J ConcorsDepartment of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Peter L AbtDepartment of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Deirdre SawinskiRenal-Electrolyte and Hypertension Division, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Roy D BloomRenal-Electrolyte and Hypertension Division, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Peter P ReeseRenal-Electrolyte and Hypertension Division, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Matthew H LevineDepartment of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.ORCID 0000-0003-4525-5827

Funding

HDAC2 Inhibition Mitigates Renal Ischemia Reperfusion InjuryR01DK106243 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI LEVINE, MATTHEW HOWARD · 2016 to 2020
$1.8M
NIDDK NIH HHS R01 DK106243
6 · The paper itself

Abstract

introductionThe new kidney allocation system (KAS) prioritizes patients based on date of dialysis initiation or waitlisting, whichever is earlier. We hypothesized that this change would increase transplant rates for patients with prolonged pretransplant dialysis times (DT) and aimed to assess the impact of prolonged DT on post-transplant outcomes.

methodsWe used United Network for Organ Sharing registry data to assess outcomes for patients added to the renal transplant waitlist from January 1, 1998 to December 31, 2010 and patients transplanted from January 1, 1998 to December 3, 2012.

resultsCompared with patients transplanted pre-emptively, patients with <5 years, 5-9 years, and ≥10 years DT had progressively decreased graft and patient survival (P < .001). The rates of short-term complications including delayed graft function, graft loss within 30 days, and patient death within 30 days were significantly higher in cohorts with ≥10 years DT than in cohorts with less DT (P < .001).

conclusionsPatients with pretransplant DT of ≥10 years had worse outcomes than patients pre-emptively transplanted or transplanted with shorter DT. Durations of dialysis dependence beyond 10 years were associated with further deterioration in short-term but not long-term post-transplant outcomes.

Indexed as

AdolescentAdultDelayed Graft FunctionFemaleFollow-Up StudiesHumansKidney TransplantationMaleMiddle AgedPrognosisRenal DialysisSurvival RateTissue DonorsTransplant RecipientsWaiting ListsYoung Adultdialysisend-stage renal diseasegraft failuregraft survivalkidney transplantation

Identifiers

PMID29656398
PMCPMC6023748

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.