Evidence map›Paper›PMID 29656382›Full record

ArticleJournal of the American Geriatrics Society2018

Opioid Prescriptions in Older Medicare Beneficiaries After the 2014 Federal Rescheduling of Hydrocodone Products.

Yong-Fang Kuo, Mukaila A Raji, Victor Liaw, Jacques Baillargeon, James S Goodwin

Abstract read
In one paragraph

Article in Journal of the American Geriatrics Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
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  4. Prescribing of Gabapentinoids with or without opioids after burn injury in the US, 2012-2018.Burns : journal of the International Society for Burn Injuries · 2022
    Article
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  11. Time Trends in Opioid Use by Dementia Severity in Long-Term Care Nursing Home Residents.Journal of the American Medical Directors Association · 2021
    Article
  12. The state of the science in opioid policy research.Drug and alcohol dependence · 2020
    Review
  13. Article
  14. Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Yong-Fang KuoDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, Texas.ORCID 0000-0003-0704-2214
Mukaila A RajiDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, Texas.
Victor LiawCollege of Natural Sciences, University of Texas at Austin, Austin, Texas.
Jacques BaillargeonDepartment of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, Texas.
James S GoodwinDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, Texas.
The University of Texas Medical Branch at Galveston · USThe University of Texas at Austin · US

Funding

UTMB Clinical and Translational Science AwardUL1TR001439 · NCATS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI URBAN, RANDALL J · 2015 to 2024
$40.0M
UTMB OAIC Research Education Component (REC)P30AG024832 · NIA · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI JAMES S. GOODWIN, MD, MELISSA M. MORROW · 2005 to 2026
$26.7M
UTMB Clinical and Translational Science AwardUL1TR000071 · NCATS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI BRASIER, ALLAN R. · 2012 to 2014
$14.4M
Patient Centered Outcomes Research in the ElderlyR24HS022134 · AHRQ · UNIVERSITY OF TEXAS MED BR GALVESTON · PI GOODWIN, MD, JAMES S. · 2013 to 2017
$4.8M
Pattern, Variation and Outcomes of Opioid Prescription in Older AdultsR01DA039192 · NIDA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI KUO, YONG-FANG, RAJI, MUKAILA A · 2016 to 2023
$3.1M
AHRQ HHS R24 HS022134NCATS NIH HHS UL1 TR000071NCATS NIH HHS UL1 TR001439NIA NIH HHS P30 AG024832NIDA NIH HHS R01 DA039192
6 · The paper itself

Abstract

objectivesTo examine how an October 2014 Drug Enforcement Administration policy reclassified hydrocodone product from schedule III to II has affected older adults, who are among the largest consumers of prescription opioids in the United States.

designRetrospective cohort study.

settingUnited States.

participantsA 20% sample of Medicare Part D beneficiaries aged 65 and older from 2013 through 2015 (> 2,500,000 beneficiaries each year) MEASUREMENTS: From January 2013 to December 2015, we calculated the monthly prevalence of opioid prescriptions and the prevalence of individuals who received prescriptions for a 90-day supply or longer (prolonged), as well as hospitalizations related to opioid toxicity in 2013 and 2015.

resultsFrom 2013 to 2015, the proportion of Medicare Part D enrollees who received a hydrocodone prescription in a year decreased from 21.9% to 18.3%. Monthly rates for hydrocodone prescriptions declined significantly in 2014. The risk of receiving prolonged opioid prescriptions decreased by approximately 7% in the multivariable analyses comparing 2015 to 2013 (prevalence ratio=0.93, 95% confidence interval (CI)=0.93-0.94). Medicare enrollees with an original entitlement because of disability or with Medicaid eligibility had smaller decreases in prolonged prescriptions and, unexpectedly, small increases in high-dose prescriptions. Opioid-related hospitalizations did not change significantly, but opioid-related hospitalizations without a documented opioid prescription increased (odds ratio=1.24, 95% CI=1.03-1.50).

conclusionThe 2014 change in hydrocodone from schedule III to schedule II was associated with modest decreases in rates of opioid use in the elderly. The unexpected increase in opioid-related hospitalizations without documented opioid prescriptions may represent an increase in illegal use.

Indexed as

Practice Patterns, Physicians'AgedAged, 80 and overAnalgesics, OpioidDrug PrescriptionsFemaleHumansHydrocodoneMaleMedicare Part DOpioid-Related DisordersRetrospective StudiesUnited StatesAnalgesics, OpioidHydrocodoneMedicareOpioidOverdoseRegulation

Identifiers

PMID29656382
PMCPMC5992099
OpenAlexW2800690753

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.