ReviewCurrent osteoporosis reports2018
Are CT-Based Finite Element Model Predictions of Femoral Bone Strength Clinically Useful?
Review in Current osteoporosis reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 62 citations in OpenAlex.
- Subject-Specific Finite Element Analysis of the Human Femur Using Radiation-Free Three-Dimensional Zero-Echo-Time Magnetic Resonance Imaging (3D ZTE MRI): A Feasibility Study.Life (Basel, Switzerland) · 2026Article
- Tuning and validation of a virtual mechanical testing pipeline for condylar stress fracture risk assessment in Thoroughbred racehorses.Royal Society open science · 2025Article
- Gender differences in L1 vertebral strength in adults 50+ using automated CT-based finite element analysis.Scientific reports · 2025Article
- Parametrized statistical appearance and shape modelling strategy to predict proximal and diaphyseal femoral fractures.Frontiers in bioengineering and biotechnology · 2025Article
- Inelastic mechanical descriptors for osteoporotic hip fracture discrimination with 3D-DXA-based nonlinear finite element models.Frontiers in bioengineering and biotechnology · 2025Article
- Advancements in Subchondral Bone Biomechanics: Insights from Computed Tomography and Micro-Computed Tomography Imaging in Equine Models.Current osteoporosis reports · 2024Review
- The Morphology of the Femur Influences the Fracture Risk during Stumbling and Falls on the Hip-A Computational Biomechanical Study.Life (Basel, Switzerland) · 2024Article
- Phantomless calibration of CT scans for hip fracture risk prediction in silico: Comparison with phantom-based calibration.PloS one · 2024Article
- Anisotropy, Anatomical Region, and Additional Variables Influence Young's Modulus of Bone: A Systematic Review and Meta-Analysis.JBMR plus · 2023Review
- The clinician's guide to prevention and treatment of osteoporosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022Article
- Personalised 3D Assessment of Trochanteric Soft Tissues Improves HIP Fracture Classification Accuracy.Annals of biomedical engineering · 2022Article
- Improving the Hip Fracture Risk Prediction with a Statistical Shape-and-Intensity Model of the Proximal Femur.Annals of biomedical engineering · 2022Article
- Osteoporosis in 10 years time: a glimpse into the future of osteoporosis.Therapeutic advances in musculoskeletal disease · 2022Article
- Finite Element Assessment of Bone Fragility from Clinical Images.Current osteoporosis reports · 2021Review
- Which experimental procedures influence the apparent proximal femoral stiffness? A parametric study.BMC musculoskeletal disorders · 2021Article
- Body Anthropometry and Bone Strength Conjointly Determine the Risk of Hip Fracture in a Sideways Fall.Annals of biomedical engineering · 2021Article
- Opportunistic diagnosis of osteoporosis, fragile bone strength and vertebral fractures from routine CT scans; a review of approved technology systems and pathways to implementation.Therapeutic advances in musculoskeletal disease · 2021Review
- A systematic approach to the scale separation problem in the development of multiscale models.PloS one · 2021Article
- A Review on Recent Advances in the Constitutive Modeling of Bone Tissue.Current osteoporosis reports · 2020Review
- Effect of CT imaging on the accuracy of the finite element modelling in bone.European radiology experimental · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewThis study reviews the available literature to compare the accuracy of areal bone mineral density derived from dual X-ray absorptiometry (DXA-aBMD) and of subject-specific finite element models derived from quantitative computed tomography (QCT-SSFE) in predicting bone strength measured experimentally on cadaver bones, as well as their clinical accuracy both in terms of discrimination and prediction. Based on this information, some basic cost-effectiveness calculations are performed to explore the use of QCT-SSFE instead of DXA-aBMD in (a) clinical studies with femoral strength as endpoint, (b) predictor of the risk of hip fracture in low bone mass patients. RECENT
findingsRecent improvements involving the use of smooth-boundary meshes, better anatomical referencing for proximal-only scans, multiple side-fall directions, and refined boundary conditions increase the predictive accuracy of QCT-SSFE. If these improvements are adopted, QCT-SSFE is always preferable over DXA-aBMD in clinical studies with femoral strength as the endpoint, while it is not yet cost-effective as a hip fracture risk predictor, although pathways that combine both QCT-SSFE and DXA-aBMD are promising.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.