Evidence map›Paper›PMID 29656328›Full record

ArticleParasitology research2018

Human colostrum action against Giardia lamblia infection influenced by hormones and advanced maternal age.

Queli Lisiane Castro Pereira, Cristiane de Castro Pernet Hara, Rubian Trindade Silva Fernandes, Danny Laura Gomes Fagundes, Aline do Carmo França-Botelho, Maria Aparecida Gomes, Eduardo Luzía França, Adenilda Cristina Honorio-França

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In one paragraph

Article in Parasitology research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Queli Lisiane Castro PereiraInstitute of Biological and Health Science, Federal University of Mato Grosso, Barra do Garças, MT, Brazil.
Cristiane de Castro Pernet HaraInstitute of Biological and Health Science, Federal University of Mato Grosso, Barra do Garças, MT, Brazil.
Rubian Trindade Silva FernandesInstitute of Biological and Health Science, Federal University of Mato Grosso, Barra do Garças, MT, Brazil.
Danny Laura Gomes FagundesInstitute of Biological and Health Science, Federal University of Mato Grosso, Barra do Garças, MT, Brazil.
Aline do Carmo França-BotelhoInstitute of Health Sciences, University Center of Planalto de Araxá, Araxá, Minas Gerais,, Brazil.
Maria Aparecida GomesDepartment of Parasitology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Eduardo Luzía FrançaInstitute of Biological and Health Science, Federal University of Mato Grosso, Barra do Garças, MT, Brazil.
Adenilda Cristina Honorio-FrançaInstitute of Biological and Health Science, Federal University of Mato Grosso, Barra do Garças, MT, Brazil. adenildachf@gmail.com.
Universidade Federal de Mato Grosso · BRCentro Universitário do Planalto de Araxá · BRUniversidade Federal de Minas Gerais · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Children are more susceptible to Giardia lamblia infection. Cells and hormones contained in human colostrum have an immunoprotective action against giardiasis, but the effects of advanced maternal age on these components are poorly understood. This study analyzed the colostrum of older women to determine melatonin and cortisol levels besides the participation of these hormones on the functional activity of phagocytes against G. lamblia. Colostrum samples were collected from younger (18 to 35 years old) and older (over 36 years old) lactating women. Colostrum samples were subjected to melatonin and cortisol determination, immunophenotyping, quantification of superoxide release, and assessment of phagocytic rate and microbicidal activity of phagocytes treated with hormones and in the presence of G. lamblia. Colostrum from mothers of advanced age contained higher melatonin and cortisol levels and a lower rate of cells expressing CD14

Indexed as

AdolescentAdultAgingAnimalsChildColostrumCross-Sectional StudiesFemaleGiardia lambliaGiardiasisHumansHydrocortisoneLactationLewis X AntigenLipopolysaccharide ReceptorsMaternal AgeHydrocortisoneLewis X AntigenLipopolysaccharide ReceptorsMelatoninSuperoxidesClimactericColostrumGiardia lambliaHormonesPhagocytes

Identifiers

PMID29656328
OpenAlexW2796957360

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.