ArticleCortex; a journal devoted to the study of the nervous system and behavior2018
Individual differences in socioemotional sensitivity are an index of salience network function.
Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
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Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.
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- Early clinical characteristics of pathologically confirmed progressive supranuclear palsy and corticobasal degeneration.Journal of neurology · 2026Article
- Prenatal maternal mood instability and child externalizing problems: An ecological momentary assessment study.Journal of affective disorders · 2025Article
- Validation of the Cognitive-Emotional Perspective Taking test in patients with neurodegeneration.Journal of Alzheimer's disease : JAD · 2025Article
- Mapping the neurodevelopmental predictors of psychopathology.Molecular psychiatry · 2025Article
- Testing an interpersonal risk pathway to suicidal ideation in adolescence: linking neural, psychological, and sociometric indices of socially relevant factors.Social cognitive and affective neuroscience · 2025Article
- Reward system atrophy relates to heightened feelings of physical closeness in Alzheimer's disease.Social cognitive and affective neuroscience · 2025Article
- Salience and default networks predict borderline personality traits and affective symptoms: a dynamic functional connectivity analysis.Frontiers in human neuroscience · 2025Article
- A neuroanatomical and cognitive model of impaired social behaviour in frontotemporal dementia.Brain : a journal of neurology · 2024Review
- Annual Research Review: The power of predictability - patterns of signals in early life shape neurodevelopment and mental health trajectories.Journal of child psychology and psychiatry, and allied disciplines · 2024Review
- Social cognition and behavioral changes in patients with posterior cortical atrophy.Journal of neurology · 2024Article
- Prenatal Exposure to Maternal Mood Entropy Is Associated With a Weakened and Inflexible Salience Network in Adolescence.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Real World Financial Mismanagement in Alzheimer's Disease, Frontotemporal Dementia, and Primary Progressive Aphasia.Journal of Alzheimer's disease : JAD · 2024Article
- Intrinsic functional and structural network organization in the macaque insula.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Disinhibition in dementia related to reduced morphometric similarity of cognitive control network.Brain communications · 2024Article
- Network Connectivity Alterations across the MAPT Mutation Clinical Spectrum.Annals of neurology · 2023Article
- Alone Together: Is Strain Experienced Concurrently by Members of Operating Room Teams?: An Event-based Study.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2023Article
- Article
- Social and non-social working memory in neurodegeneration.Neurobiology of disease · 2023Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Connectivity in intrinsically connected networks (ICNs) may predict individual differences in cognition and behavior. The drastic alterations in socioemotional awareness of patients with behavioral variant frontotemporal dementia (bvFTD) are presumed to arise from changes in one such ICN, the salience network (SN). We examined how individual differences in SN connectivity are reflected in overt social behavior in healthy individuals and patients, both to provide neuroscientific insight into this key brain-behavior relationship, and to provide a practical tool to diagnose patients with early bvFTD. We measured SN functional connectivity and socioemotional sensitivity in 65 healthy older adults and 103 patients in the earliest stage [Clinical Dementia Rating (CDR) Scale score ≤1] of five neurodegenerative diseases [14 bvFTD, 29 Alzheimer's disease (AD), 20 progressive supranuclear palsy (PSP), 21 semantic variant primary progressive aphasia (svPPA), and 19 non-fluent variant primary progressive aphasia (nfvPPA)]. All participants underwent resting-state functional imaging and an informant described their responsiveness to subtle emotional expressions using the Revised Self-Monitoring Scale (RSMS). Higher functional connectivity in the SN, predominantly between the right anterior insula (AI) and both "hub" cortical and "interoceptive" subcortical nodes, predicted socioemotional sensitivity among healthy individuals, showing that socioemotional sensitivity is a behavioral marker of SN function, and particularly of right AI functional connectivity. The continuity of this relationship in both healthy and neurologically affected individuals highlights the role of socioemotional sensitivity as an early diagnostic marker of SN connectivity. Clinically, this is particularly important for identification of patients in the earliest stage of bvFTD, where the SN is selectively vulnerable.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.