ArticleBiochimica et biophysica acta. General subjects2018
Selenium supplementation prevents metabolic and transcriptomic responses to cadmium in mouse lung.
Article in Biochimica et biophysica acta. General subjects, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The trial behind it
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Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- Occupation Associated with Altered Steroid Hormone Metabolism in Men: A Cross-Sectional Metabolome-Wide Association Study.Research square · 2026Article
- Single-Cell Multiome Impact of Prenatal Heavy Metal Exposure on Early Airway Development.American journal of respiratory cell and molecular biology · 2026Article
- The effects of combined low-dose cadmium and deltamethrin on mitochondrial bioenergetics and metabolism in human lung fibroblasts.Toxicology reports · 2025Article
- Amino Acid Associations in Healthy and Unhealthy Obesity.The Journal of nutrition · 2025Article
- Cadmium exposure following early-life respiratory syncytial virus infection promotes lung fibrosis through autophagy inhibition.Toxicological sciences : an official journal of the Society of Toxicology · 2025Article
- Multi-Omics Assessment of Puff Volume-Mediated Salivary Biomarkers of Metal Exposure and Oxidative Injury Associated with Electronic Nicotine Delivery Systems.Environmental health perspectives · 2025Article
- Alleviation of Lipid Disorder and Liver Damage in High-Fat Diet-Induced Obese Mice by Selenium-EnrichedNutrients · 2024Article
- Redox organization of living systems.Free radical biology & medicine · 2024Review
- Protein S-palmitoylation enhances profibrotic signaling in response to cadmium.Toxicology and applied pharmacology · 2024Article
- Study on the relationship between selenium and cadmium in diseased human lungs.Advances in redox research · 2023Article
- Low-Dose Cadmium Potentiates Metabolic Reprogramming Following Early-Life Respiratory Syncytial Virus Infection.Toxicological sciences : an official journal of the Society of Toxicology · 2022Article
- Protective Effect of Mitophagy Regulated by mTOR Signaling Pathway in Liver Fibrosis Associated with Selenium.Nutrients · 2022Article
- Omics Integration for Mitochondria Systems Biology.Antioxidants & redox signaling · 2020Review
- Understanding mixed environmental exposures using metabolomics via a hierarchical community network model in a cohort of California women in 1960's.Reproductive toxicology (Elmsford, N.Y.) · 2020Article
- Metabolome Wide Association Study of serum DDT and DDE in Pregnancy and Early Postpartum.Reproductive toxicology (Elmsford, N.Y.) · 2020Article
- The Role of Selenium in Arsenic and Cadmium Toxicity: an Updated Review of Scientific Literature.Biological trace element research · 2020Review
- Environmental Cadmium Enhances Lung Injury by Respiratory Syncytial Virus Infection.The American journal of pathology · 2019Article
- Metabolome Wide Association Study of Serum Poly and Perfluoroalkyl Substances (PFASs) in Pregnancy and Early Postpartum.Reproductive toxicology (Elmsford, N.Y.) · 2019Article
- Redox Systems Biology of Nutrition and Oxidative Stress.The Journal of nutrition · 2019Article
- Low-dose cadmium disrupts mitochondrial citric acid cycle and lipid metabolism in mouse lung.Free radical biology & medicine · 2019Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe protective effect of selenium (Se) on cadmium (Cd) toxicity is well documented, but underlying mechanisms are unclear.
methodsMale mice fed standard diet were given Cd (CdCl
resultsMice treated with Cd had higher lung Cd content (1.7 ± 0.4 pmol/mg protein) than control mice (0.8 ± 0.3 pmol/mg protein) or mice treated with Cd and Se (0.4 ± 0.1 pmol/mg protein). Gene set enrichment analysis of transcriptomics data showed that Se prevented Cd effects on inflammatory and myogenesis genes and diminished Cd effects on several other pathways. Similarly, Se prevented Cd-disrupted metabolic pathways in amino acid metabolism and urea cycle. Integrated transcriptome and metabolome network analysis showed that Cd treatment had a network structure with fewer gene-metabolite clusters compared to control. Centrality measurements showed that Se counteracted changes in a group of Cd-responsive genes including Zdhhc11, (protein-cysteine S-palmitoyltransferase), Ighg1 (immunoglobulin heavy constant gamma-1) and associated changes in metabolite concentrations.
conclusionCo-administration of Se with Cd prevented Cd increase in lung and prevented Cd-associated pathway and network responses of the transcriptome and metabolome. Se protection against Cd toxicity in lung involves complex systems responses. GENERAL SIGNIFICANCE: Environmental Cd stimulates proinflammatory and profibrotic signaling. The present results indicate that dietary or supplemental Se could be useful to mitigate Cd toxicity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.