Evidence map›Paper›PMID 29656121›Full record

ReviewBiochimica et biophysica acta. General subjects2018

Molecular mechanism of selenoprotein P synthesis.

Sumangala Shetty, Paul R Copeland

Abstract readReview
In one paragraph

Review in Biochimica et biophysica acta. General subjects, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Biological and Catalytic Properties of Selenoproteins.International journal of molecular sciences · 2023
    Review
  6. Article
  7. Selenoprotein: Potential Player in Redox Regulation inAntioxidants (Basel, Switzerland) · 2022
    Article
  8. Article
  9. Review
  10. Review
  11. Selenium at theFrontiers in neuroscience · 2021
    Review
  12. The algal selenoproteomes.BMC genomics · 2020
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sumangala ShettyDepartment of Biochemistry and Molecular Biology, Rutgers - Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, United States.
Paul R CopelandDepartment of Biochemistry and Molecular Biology, Rutgers - Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, United States. Electronic address: paul.copeland@rutgers.edu.

Funding

Functional Analysis of SBP2 and Selenocysteine IncorporationR01GM077073 · NIGMS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI COPELAND, PAUL R · 2006 to 2022
$5.5M
Development of a zebrafish model for selenoprotein synthesis and functionR21HD083616 · NICHD · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI COPELAND, PAUL R · 2016 to 2017
$428k
NICHD NIH HHS R21 HD083616NIGMS NIH HHS R01 GM077073
6 · The paper itself

Abstract

backgroundSelenoprotein synthesis requires the reinterpretation of a UGA stop codon as one that encodes selenocysteine (Sec), a process that requires a set of dedicated translation factors. Among the mammalian selenoproteins, Selenoprotein P (SELENOP) is unique as it contains a selenocysteine-rich domain that requires multiple Sec incorporation events. SCOPE OF REVIEW: In this review we elaborate on new data and current models that provide insight into how SELENOP is made. MAJOR

conclusionsSELENOP synthesis requires a specific set of factors and conditions. GENERAL SIGNIFICANCE: As the key protein required for proper selenium distribution, SELENOP stands out as a lynchpin selenoprotein that is essential for male fertility, proper neurologic function and selenium metabolism.

Indexed as

SBP2SECISSECISBP2LSeleniumSelenocysteineSelenoprotein P

Identifiers

PMID29656121
PMCPMC6188828

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.