Evidence map›Paper›PMID 29656108›Full record

ArticleMolecular metabolism2018

Epoxygenase inactivation exacerbates diet and aging-associated metabolic dysfunction resulting from impaired adipogenesis.

Antoni Olona, Ximena Terra, Jeong-Hun Ko, Carme Grau-Bové, Montserrat Pinent, Anna Ardevol, Ana Garcia Diaz, Aida Moreno-Moral, Matthew Edin, David Bishop-Bailey and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Arachidonic acid in aging: New roles for old players.Journal of advanced research · 2025
    Review
  4. Article
  5. Review
  6. Increased toxicity and retention of perflourooctane sulfonate (PFOS) in humanized CYP2B6-Transgenic mice compared to Cyp2b-null mice is relieved by a high-fat diet (HFD).Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2021
    Article
  7. Review
  8. Quantitative proteomics to study aging in rabbit liver.Mechanisms of ageing and development · 2020
    Article
  9. Frontiers in pharmacology · 2020
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 4 countries.

Antoni OlonaCentre for Complement and Inflammation Research, Imperial College London, London, W12 0NN, UK.
Ximena TerraCentre for Complement and Inflammation Research, Imperial College London, London, W12 0NN, UK; Mobiofood Research Group, Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili, 43007, Tarragona, Spain.
Jeong-Hun KoCentre for Complement and Inflammation Research, Imperial College London, London, W12 0NN, UK.
Carme Grau-BovéCentre for Complement and Inflammation Research, Imperial College London, London, W12 0NN, UK; Mobiofood Research Group, Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili, 43007, Tarragona, Spain.
Montserrat PinentMobiofood Research Group, Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili, 43007, Tarragona, Spain.
Anna ArdevolMobiofood Research Group, Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili, 43007, Tarragona, Spain.
Ana Garcia DiazRenal and Vascular Inflammation Section, Department of Medicine, Imperial College London, London, W12 0NN, UK.
Aida Moreno-MoralDuke-NUS Medical School, National University of Singapore, 169857, Singapore.
Matthew EdinDivision of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.
David Bishop-BaileyComparative Biomedical Sciences, Royal Veterinary College, London, NW1 0TU, UK.
Darryl C ZeldinDivision of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.
Timothy J AitmanCentre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Enrico PetrettoDuke-NUS Medical School, National University of Singapore, 169857, Singapore.
Mayte BlayMobiofood Research Group, Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili, 43007, Tarragona, Spain.
Jacques BehmoarasCentre for Complement and Inflammation Research, Imperial College London, London, W12 0NN, UK. Electronic address: jacques.behmoaras@imperial.ac.uk.
Centre for Inflammation Research · GBUniversitat Rovira i Virgili · ESNational Institutes of Health · USNational University of Singapore · SGImperial College London · GBRoyal Veterinary College · GBUniversity of Edinburgh · GB

Funding

Characterization And Functional Significance Of P450 Arachidonate EpoxygenasesZIAES025034 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI ZELDIN, DARRYL C · 2009 to 2025
$18.6M
P450 Arachidonate EpoxygenasesZ01ES025034 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI ZELDIN, DARRYL C · 1995 to 2008
$2.2M
Chief Scientist Office SGP/1Medical Research Council MC_PC_15080Medical Research Council MR/M004716/1Medical Research Council MR/N005902/1Medical Research Council MR/N01121X/1NIEHS NIH HHS Z01 ES025034
6 · The paper itself

Abstract

objectiveWhen molecular drivers of healthy adipogenesis are perturbed, this can cause hepatic steatosis. The role of arachidonic acid (AA) and its downstream enzymatic cascades, such as cyclooxygenase, in adipogenesis is well established. The exact contribution of the P450 epoxygenase pathway, however, remains to be established. Enzymes belonging to this pathway are mainly encoded by the CYP2J locus which shows extensive allelic expansion in mice. Here we aimed to establish the role of endogenous epoxygenase during adipogenesis under homeostatic and metabolic stress conditions.

methodsWe took advantage of the simpler genetic architecture of the Cyp2j locus in the rat and used a Cyp2j4 (orthologue of human CYP2J2) knockout rat in two models of metabolic dysfunction: physiological aging and cafeteria diet (CAF). The phenotyping of Cyp2j4

resultsWe report that Cyp2j4 deletion causes adipocyte dysfunction under metabolic challenges. This is characterized by (i) down-regulation of white adipose tissue (WAT) PPARγ and C/EBPα, (ii) adipocyte hypertrophy, (iii) extracellular matrix remodeling, and (iv) alternative usage of AA pathway. Specifically, in Cyp2j4

conclusionThese results suggest that AA epoxygenases are essential regulators of healthy adipogenesis. Our results uncover their synergistic role in fine-tuning AA pathway in obesity-mediated hepatic steatosis.

Indexed as

AdipogenesisAdipose Tissue, WhiteAgingAnimalsArachidonic AcidCCAAT-Enhancer-Binding ProteinsCells, CulturedCytochrome P450 Family 2Diet, Carbohydrate LoadingDiet, High-FatExtracellular MatrixGluconeogenesisLipid MetabolismMaleObesityPPAR gammaArachidonic AcidCCAAT-Enhancer-Binding ProteinsCyp2j4 protein, ratCytochrome P450 Family 2PPAR gammaAdipogenesisAgingArachidonic acidCafeteria dietCytochrome P450 2j4Steatosis

Identifiers

PMID29656108
PMCPMC6001407
OpenAlexW2790685128

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.