ReviewNeuroImage2019
Delineation of early brain development from fetuses to infants with diffusion MRI and beyond.
Review in NeuroImage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 150 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
150 citing papers in PubMed, 1 synthesis or guideline pooled it, 280 citations in OpenAlex.
- Pooled it
- Neurite orientation dispersion and density imaging for preoperative evaluation of cerebral microstructure and neurodevelopment in children with congenital heart disease.Quantitative imaging in medicine and surgery · 2026Article
- Spatial transcriptomics reveal developmental dynamics of the human cerebral cortex and striatum.Science China. Life sciences · 2026Article
- Air pollution and autism-like traits: Sensitive periods and joint effects of exposure to sources and constituents of fine particulate matter.Environmental research · 2026Article
- Brain structural and functional connectivity converge prenatally but diverge after birth.PLoS biology · 2026Article
- Congenital blindness reduces myelination in human visual cortex.Science advances · 2026Article
- Gene dosage effects of 22q11.2 copy number variants on in-vivo measures of white matter axonal density and dispersion.Molecular psychiatry · 2026Article
- Developmental human brain connectome from fetal stage to early childhood.Developmental cognitive neuroscience · 2026Review
- Predicting Outcome After Newborn Stroke: A Lesion Network Mapping Study Leveraging Large-Scale Data.Stroke · 2026Article
- CNNT-Net: a novel deep learning-based framework for estimating high-quality fiber orientation distributions from single-shell dMRI.Physical and engineering sciences in medicine · 2026Article
- Early Relational Health and its Impact on the Developing Brain: A Scoping Review.Clinical child and family psychology review · 2026Article
- Cross-population white matter atlas creation for concurrent mapping of brain connections in neonates and adults with diffusion MRI tractography.Fundamental research · 2026Article
- Mapping Functional Brain Organization Using Artificial Intelligence.Chemical & biomedical imaging · 2026Review
- Typical development of the human fetal subplate: Regional heterogeneity, growth, and asymmetry assessed by in vivo T2-weighted MRI.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Testing retrogenesis and physiological explanations for tract-wise white matter aging: links to developmental order, fiber calibre, and vascularization.GeroScience · 2026Article
- Revolutionizing Pediatric Neurophysiology With Magnetoencephalography.Psychophysiology · 2026Review
- High-resolution in utero SV2A PET imaging of the nonhuman primate brain using the NeuroEXPLORER.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Article
- Detailed Delineation of the Fetal Brain in Diffusion MRI via Multi-Task Learning.IEEE transactions on medical imaging · 2026Article
- Shared and Unique Connectivity Signatures of Reading and Language Deficits.Journal of cognitive neuroscience · 2026Article
- Functional changes of precuneus architecture across newborns, infants, and early adolescents.Scientific reports · 2026Article
90 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Dynamic macrostructural and microstructural changes take place from the mid-fetal stage to 2 years after birth. Delineating structural changes of the brain during early development provides new insights into the complicated processes of both typical development and the pathological mechanisms underlying various psychiatric and neurological disorders including autism, attention deficit hyperactivity disorder and schizophrenia. Decades of histological studies have identified strong spatial and functional maturation gradients in human brain gray and white matter. The recent improvements in magnetic resonance imaging (MRI) techniques, especially diffusion MRI (dMRI), relaxometry imaging, and magnetization transfer imaging (MTI) have provided unprecedented opportunities to non-invasively quantify and map the early developmental changes at whole brain and regional levels. Here, we review the recent advances in understanding early brain structural development during the second half of gestation and the first two postnatal years using modern MR techniques. Specifically, we review studies that delineate the emergence and microstructural maturation of white matter tracts, as well as dynamic mapping of inhomogeneous cortical microstructural organization unique to fetuses and infants. These imaging studies converge into maturational curves of MRI measurements that are distinctive across different white matter tracts and cortical regions. Furthermore, contemporary models offering biophysical interpretations of the dMRI-derived measurements are illustrated to infer the underlying microstructural changes. Collectively, this review summarizes findings that contribute to charting spatiotemporally heterogeneous gray and white matter structural development, offering MRI-based biomarkers of typical brain development and setting the stage for understanding aberrant brain development in neurodevelopmental disorders.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.