Evidence map›Paper›PMID 29655632›Full record

ArticleVaccine2018

Ag85A-specific CD4

Hannah J Metcalfe, Lucia Biffar, Sabine Steinbach, Efrain Guzman, Tim Connelley, Ivan Morrison, H Martin Vordermeier, Bernardo Villarreal-Ramos

Open access · hybridAbstract read
In one paragraph

Article in Vaccine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Video Endoscopy-Guided Intrabronchial Spray Inoculation ofFrontiers in veterinary science · 2022
    Article
  7. Article
  8. Tuberculosis vaccine development: from classic to clinical candidates.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Hannah J MetcalfeTB Immunology and Vaccinology Team, Department of Bacteriology, Animal and Plant Health Agency, Weybridge, Surrey KT15 3NB, UK; Immunity Division, The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK.
Lucia BiffarTB Immunology and Vaccinology Team, Department of Bacteriology, Animal and Plant Health Agency, Weybridge, Surrey KT15 3NB, UK.
Sabine SteinbachTB Immunology and Vaccinology Team, Department of Bacteriology, Animal and Plant Health Agency, Weybridge, Surrey KT15 3NB, UK.
Efrain GuzmanThe Pirbright Institute Ash Road, Pirbright, Surrey GU24 0NF, UK.
Tim ConnelleyImmunity Division, The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK.
Ivan MorrisonImmunity Division, The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK.
H Martin VordermeierTB Immunology and Vaccinology Team, Department of Bacteriology, Animal and Plant Health Agency, Weybridge, Surrey KT15 3NB, UK.
Bernardo Villarreal-RamosTB Immunology and Vaccinology Team, Department of Bacteriology, Animal and Plant Health Agency, Weybridge, Surrey KT15 3NB, UK. Electronic address: Bernardo.Villarreal-Ramos@apha.gsi.gov.uk.
Animal and Plant Health Agency · GBRoslin Institute · GBThe Pirbright Institute · GBUniversity of Edinburgh · GB

Funding

Biotechnology and Biological Sciences Research Council BB/K010018/1Biotechnology and Biological Sciences Research Council BBS/E/I/00007038
6 · The paper itself

Abstract

There is a need to improve the efficacy of the BCG vaccine against human and bovine tuberculosis. Previous data showed that boosting bacilli Calmette-Guerin (BCG)-vaccinated cattle with a recombinant attenuated human type 5 adenovirally vectored subunit vaccine (Ad5-85A) increased BCG protection and was associated with increased frequency of Ag85A-specific CD4

Indexed as

AcyltransferasesAdenoviruses, HumanAnimalsAntigens, BacterialCattleCD4-Positive T-LymphocytesDrug CarriersImmunization, SecondaryInflammationMycobacterium bovisTreatment OutcomeTuberculosis, BovineTuberculosis VaccinesVaccines, SyntheticAcyltransferasesantigen 85A, Mycobacterium tuberculosisAntigens, BacterialDrug CarriersTuberculosis VaccinesVaccines, SyntheticAntigen specificCytokinesMycobacteria killingT-cell lines

Identifiers

PMID29655632
PMCPMC5937909
OpenAlexW2796899643

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.