Evidence map›Paper›PMID 29655451›Full record

ReviewNeurologic clinics2018

Muscle-Specific Tyrosine Kinase and Myasthenia Gravis Owing to Other Antibodies.

Michael H Rivner, Mamatha Pasnoor, Mazen M Dimachkie, Richard J Barohn, Lin Mei

Abstract readReview
In one paragraph

Review in Neurologic clinics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Disease severity and response to treatment in Iranian patients with myasthenia gravis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Article
  10. The Role of Plasma Exchange in the Treatment of Refractory Autoimmune Neurological Diseases: a Narrative Review.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2021
    Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Controversies in Ocular Myasthenia Gravis.Frontiers in neurology · 2020
    Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Michael H RivnerEMG Lab, Augusta University, 1120 15th Street, BP-4390, Augusta, GA 30912, USA. Electronic address: MRIVNER@augusta.edu.
Mamatha PasnoorDepartment of Neurology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA.
Mazen M DimachkieDepartment of Neurology, University of Kansas Medical Center, 3599 Rainbow Boulevard, Mail Stop 2012, Kansas City, KS 66103, USA.
Richard J BarohnDepartment of Neurology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Mail Stop 4017, Kansas City, KS 66160, USA.
Lin MeiDepartment of Neuroscience and Regenerative Medicine, Augusta University, 1120 15th Street, CA-2014, Augusta, GA 30912, USA.

Funding

Characterization of Agrin/LRP4 Antibody-Positive Myasthenia GravisR01NS090083 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI MEI, LIN · 2015 to 2019
$2.9M
Swedish APP mutation and NMJ decline in Alzheimer's diseaseR01AG051510 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI XIONG, WEN-CHENG, ZIGMOND, RICHARD E · 2015 to 2024
$2.6M
NIA NIH HHS R01 AG051510NINDS NIH HHS R01 NS090083
6 · The paper itself

Abstract

Around 20% of patients with myasthenia gravis are acetylcholine receptor antibody negative; muscle-specific tyrosine kinase antibodies (MuSK) were identified as the cause of myasthenia gravis in 30% to 40% of these cases. Anti MuSK myasthenia gravis is associated with specific clinical phenotypes. One is a bulbar form with fewer ocular symptoms. Others show an isolated head drop or symptoms indistinguishable from acetylcholine receptor-positive myasthenia gravis. These patients usually respond well to immunosuppressive therapy, but not as well to cholinesterase inhibitors. Other antibodies associated with myasthenia gravis, including low-density lipoprotein receptor-related protein 4, are discussed.

Indexed as

AutoantibodiesAutoantigensHumansMyasthenia GravisNeuromuscular JunctionPhenotypeReceptor Protein-Tyrosine KinasesReceptors, CholinergicAutoantibodiesAutoantigensMUSK protein, humanReceptor Protein-Tyrosine KinasesReceptors, CholinergicAgrinCortactinLRP4MuSKMyasthenia gravisRapsyn

Identifiers

PMID29655451
PMCPMC6051709

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.