Evidence map›Paper›PMID 29655409›Full record

ReviewThe Kaohsiung journal of medical sciences2018

Orthodontic tooth movement: The biology and clinical implications.

Yina Li, Laura A Jacox, Shannyn H Little, Ching-Chang Ko

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Kaohsiung journal of medical sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04999150 (A Split-Mouth Randomized Clinical Trial for the Comparison of Corticotomy and Micro-Osteoperforations During Canine Retraction), which is not on this map. Cited by 207 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
207citing papers in PubMed, 6 pooled it
9.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04999150 nacompletednot on this map

A Split-Mouth Randomized Clinical Trial for the Comparison of Corticotomy and Micro-Osteoperforations During Canine Retraction: A Pilot Study

TypeinterventionalSponsorUniversity of Puerto RicoRan2018 to 2020Enrolled13ConditionsMalocclusion, Class I/IIArmsMicro-Osteoperforations, Corticotomy
3 · Its place in the literature

Who cites it

207 citing papers in PubMed, 6 syntheses or guidelines pooled it, 413 citations in OpenAlex.

  1. Pooled it
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  13. GDF15 modulates aging-associated adaptions in the mechanoresponse of periodontal ligament fibroblasts.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2026
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147 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yina LiDepartment of Orthodontics, School of Dentistry, University of North Carolina, Chapel Hill, NC, USA.
Laura A JacoxDepartment of Orthodontics, School of Dentistry, University of North Carolina, Chapel Hill, NC, USA.
Shannyn H LittleDepartment of Orthodontics, School of Dentistry, University of North Carolina, Chapel Hill, NC, USA.
Ching-Chang KoDepartment of Orthodontics, School of Dentistry, University of North Carolina, Chapel Hill, NC, USA. Electronic address: Ching-Chang_Ko@unc.edu.
University of North Carolina at Chapel Hill · US

Funding

Engineering novel bio-inspired materials for stem-cell mediated bone regenerationR01DE022816 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KO, CHING-CHANG · 2014 to 2018
$2.0M
NIDCR NIH HHS R01 DE022816
6 · The paper itself

Abstract

Orthodontic tooth movement relies on coordinated tissue resorption and formation in the surrounding bone and periodontal ligament. Tooth loading causes local hypoxia and fluid flow, initiating an aseptic inflammatory cascade culminating in osteoclast resorption in areas of compression and osteoblast deposition in areas of tension. Compression and tension are associated with particular signaling factors, establishing local gradients to regulate remodeling of the bone and periodontal ligament for tooth displacement. Key regulators of inflammation and tissue turnover include secreted factors like RANK ligand and osteoprotegerin, transcription factors such as RUNX2 and hypoxia-inducible factor, cytokines, prostaglandins, tissue necrosis factors, and proteases, among others. Inflammation occurred during tooth movement needs to be well controlled, as dysregulated inflammation leads to tissue destruction manifested in orthodontic-induced root resorption and periodontal disease. Understanding the biology has profound clinical implications especially in the area of accelerating orthodontic tooth movement. Surgical, pharmacological, and physical interventions are being tested to move teeth faster to reduce treatment times and time-dependent adverse outcomes. Future developments in acceleratory technology and custom appliances will allow orthodontic tooth movement to occur more efficiently and safely.

Indexed as

Mechanotransduction, CellularBiomechanical PhenomenaBone ResorptionCore Binding Factor Alpha 1 SubunitCytokinesGene Expression RegulationHumansHypoxia-Inducible Factor 1, alpha SubunitOsteoblastsOsteoclastsOsteogenesisOsteoprotegerinPeriodontal LigamentRANK LigandToothTooth Movement TechniquesCore Binding Factor Alpha 1 SubunitCytokinesHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitOsteoprotegerinRANK LigandRUNX2 protein, humanTNFRSF11B protein, humanTNFSF11 protein, humanAccelerated tooth movementBone remodelingOrthodontic tooth movementPeriodontal ligament

Identifiers

PMID29655409
PMCPMC11915602
OpenAlexW2792494793

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.