ReviewThe Kaohsiung journal of medical sciences2018
Aggregatibacter (Actinobacillus) actimycetemcomitans leukotoxin and human periodontitis - A historic review with emphasis on JP2.
Review in The Kaohsiung journal of medical sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- The microbiota in eosinophilic esophagitis: A systematic review.Journal of gastroenterology and hepatology · 2022Pooled it
- Prevalence of the JP2 genotype of Aggregatibacter actinomycetemcomitans in the world population: a systematic review.Clinical oral investigations · 2022Pooled it
- Fimbriae potentiateCurrent research in microbial sciences · 2026Review
- Investigating oral microbiome profiles of children with cleft lip and palate in different states of caries.Journal of oral microbiology · 2026Article
- Peridontopathogenic key species in correlation to the current classification system.Clinical oral investigations · 2025Article
- Experimental Inoculation ofInternational journal of molecular sciences · 2024Article
- Article
- Persister Cell Formation and ElevatedMicroorganisms · 2023Article
- Aggregatibacter actinomycetemcomitans infection in a 15-year-old boy with pulmonary empyema: a case report and review of literature.Italian journal of pediatrics · 2023Review
- Proteomic Characterization of the Oral PathogenPathogens (Basel, Switzerland) · 2022Article
- The Highly Leukotoxic JP2 Genotype ofPathogens (Basel, Switzerland) · 2022Article
- Aggregatibacter actinomycetemcomitans: From Basic to Advanced Research.Advances in experimental medicine and biology · 2022Article
- CD18 Mediates Neutrophil Imperviousness to theFrontiers in immunology · 2022Article
- Multilocus Sequence Typing of Aggregatibacter actinomycetemcomitans Competently Depicts the Population Structure of the Species.Microbiology spectrum · 2021Article
- Prevalence of JP2 and Non-JP2 Genotypes ofPathogens (Basel, Switzerland) · 2021Article
- Multilocus Sequence Typing of Non-JP2 Serotype bFrontiers in cellular and infection microbiology · 2021Article
- Rhamnolipids and surfactin inhibit the growth or formation of oral bacterial biofilm.BMC microbiology · 2020Article
- Characterization ofVaccines · 2020Article
- Toll-Like Receptor Signaling and Immune Regulatory Lymphocytes in Periodontal Disease.International journal of molecular sciences · 2020Review
- Virulence and Pathogenicity Properties ofPathogens (Basel, Switzerland) · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aggregatibacter (Actinobacillus) actimycetemcomitans (Aa) is a gram-negative bacterium that colonizes the human oral cavity and is causative agent for localized aggressive (juvenile) periodontitis (AgP). In the middle of 1990s, a specific JP2 clone of belonging to the cluster of serotype b strains of Aa with highly leukotoxicity (leukotoxin, LtxA) able to kill human immune cells was isolated. JP2 clone of Aa was strongly associated with in particularly in rapidly progressing forms of aggressive periodontitis. The JP2 clone of Aa is transmitted through close contacts. Therefore, AgP patients need intense monitoring of their periodontal status as the risk for developing severely progressing periodontitis lesions are relatively high. Furthermore, timely periodontal treatment, including periodontal surgery supplemented by the use of antibiotics, is warranted. More importantly, periodontal attachment loss should be prevented by early detection of the JP2 clone of Aa by microbial diagnosis testing and/or preventive means.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.