SynthesisMaternal & child nutrition2018
Infant formula feeding practices associated with rapid weight gain: A systematic review.
Synthesis in Maternal & child nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 10 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
74 citing papers in PubMed, 10 syntheses or guidelines pooled it.
- Mothers' Experiences of Formula Feeding Support in the UK: A Qualitative Systematic Review.Maternal & child nutrition · 2026Pooled it
- Assessing the impact of obesity interventions in the early years: a systematic review of UK-based studies.BMJ open · 2024Pooled it
- Higher versus lower protein intake in formula-fed term infants.The Cochrane database of systematic reviews · 2023Pooled it
- Integrative Review of Mental Health and Feeding Styles in Parents of Bottle-Fed Infants.Journal of obstetric, gynecologic, and neonatal nursing : JOGNN · 2023Pooled it
- Protein Intake from Birth to 2 Years and Obesity Outcomes in Later Childhood and Adolescence: A Systematic Review of Prospective Cohort Studies.Advances in nutrition (Bethesda, Md.) · 2021Pooled it
- Addressing obesity in the first 1000 days in high risk infants: Systematic review.Maternal & child nutrition · 2021Pooled it
- Milk Fat Globule Membrane Supplementation in Children: Systematic Review with Meta-Analysis.Nutrients · 2021Pooled it
- Understanding rapid infant weight gain prevention: a systematic review of quantitative and qualitative evidence.European journal of public health · 2020Pooled it
- Clinical audit in the pediatric primary care office and overweight prevention in toddlers.BMC pediatrics · 2020Pooled it
- Infant formula feeding practices associated with rapid weight gain: A systematic review.Maternal & child nutrition · 2018Pooled it
- Infant hyperglycemic excursions by saliva 1,5-anhydroglucitol varied by weight status, rapid weight gain, and mode of feeding: an exploratory secondary analysis.The American journal of clinical nutrition · 2026Trial
- Milk phospholipid-coated lipid droplets modulate the infant gut microbiota and metabolome influencing weight gain.Microbiome · 2025Trial
- Designing and developing a mobile app (BeBo) in a randomized controlled trial study to promote breastfeeding among Vietnamese mothers.International breastfeeding journal · 2023Trial
- Sleep SAAF responsive parenting intervention improves mothers' feeding practices: a randomized controlled trial among African American mother-infant dyads.The international journal of behavioral nutrition and physical activity · 2022Trial
- Patterns and Predictors of Breast Milk Feeding from Birth to Age 4 Months among Primiparous African American Mother-Infant Dyads.Nutrients · 2022Trial
- Measuring breakfast dietary patterns in Spanish youth: Reliability of the Spanish Youth Breakfast Consumption Questionnaire (SYBC-Q).Nutrition and health · 2026Article
- Transactional Associations Between Bottle to Bed and Infant Sleep Problems Over the First Year.Journal of sleep research · 2026Article
- Food and Drug Administration Expert Panel on Infant Formula "Operation Stork Speed" June 2025: Part 1, Nutrient Considerations.Advances in nutrition (Bethesda, Md.) · 2026Review
- Predicting rapid weight gain in six-month-old infants: an exploratory modeling study.Pediatric research · 2026Article
- Infant social withdrawal and rapid infant weight gain.International journal of obesity (2005) · 2026Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Excess or rapid weight gain during the first 2 years of life is associated with an increased risk of later childhood and adult overweight and obesity. When compared with breastfed infants, formula fed infants are more likely to experience excess or rapid weight gain, and this increased risk in formula fed infant populations may be due to a number of different mechanisms. These mechanisms include the nutrient composition of the formula and the way formula is prepared and provided to infants. This systematic literature review examines the association between formula feeding practice and excess or rapid weight gain. This review explores these different mechanisms and provides practical recommendations for best practice formula feeding to reduce rapid weight gain. Eighteen studies are included in this review. The findings are complicated by the challenges in study design and accuracy of measurements. Nevertheless, there are some potential recommendations for best practice formula feeding that may reduce excess or rapid weight gain, such as providing formula with lower protein content, not adding cereals into bottles, not putting a baby to bed with a bottle, and not overfeeding formula. Although further well designed studies are required before more firm recommendations can be made.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.