Evidence map›Paper›PMID 29654571›Full record

Observational studyIndian journal of pediatrics2018

The Role of Presepsin Obtained from Tracheal Aspirates in the Diagnosis of Early Onset Pneumonia in Intubated Newborns.

Dragana Savić, Aleksandra Simović, Slavica Marković, Gordana Kostić, Biljana Vuletić, Snezana Radivojević, Marina Lišanin, Zoran Igrutinović, Radisa Pavlović

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Indian journal of pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. The spectrum of pneumonia among intubated neonates in the neonatal intensive care unit.Journal of perinatology : official journal of the California Perinatal Association · 2024
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Dragana SavićFaculty of Medical Sciences, Department of Pediatrics, University of Kragujevac, Kragujevac, Serbia.
Aleksandra SimovićFaculty of Medical Sciences, Department of Pediatrics, University of Kragujevac, Kragujevac, Serbia.
Slavica MarkovićFaculty of Medical Sciences, Department of Pediatrics, University of Kragujevac, Kragujevac, Serbia.
Gordana KostićFaculty of Medical Sciences, Department of Pediatrics, University of Kragujevac, Kragujevac, Serbia.
Biljana VuletićFaculty of Medical Sciences, Department of Pediatrics, University of Kragujevac, Kragujevac, Serbia.
Snezana RadivojevićLaboratory Diagnostic Service, Clinical Center Kragujevac, Kragujevac, Serbia.
Marina LišaninLaboratory Diagnostic Service, Clinical Center Kragujevac, Kragujevac, Serbia.
Zoran IgrutinovićFaculty of Medical Sciences, Department of Pediatrics, University of Kragujevac, Kragujevac, Serbia.
Radisa PavlovićFaculty of Medical Sciences, Department of Clinical Pharmacy, University of Kragujevac, Kragujevac, Serbia. rpavlovic@medf.kg.ac.rs.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the role of presepsin obtained from tracheal aspirate of intubated newborns in the diagnosis of early neonatal pneumonia.

methodsA cross-sectional observational study was performed on 60 intubated newborns during the two-year period. Tracheal aspirate for examination was taken in aseptic conditions in usual toilets, by lavage with 2 ml of 0.9% NaCl in Mucus suction set. On the same day, presepsin (blood) was measured.

resultsThere were 34 newborns in the examined group (with pneumonia) and 26 in the control group. Patient groups were similar regarding demographic characteristics related to gender and Apgar score. The coefficients of simple linear correlation revealed the statistically significant connection between presepsin (from tracheal aspirate) and birth body weight, presepsin (plasma), maternal infection and pneumonia. Significant differences in the values of presepsin (from tracheal aspirate) (p < 0.001) and birth body weight (p = 0.036) were found.

conclusionsIn intubated newborns, measurements of presepsin obtained from tracheal aspirate suggested that it can be used as a complementary marker in diagnosing early onset neonatal pneumonia.

Indexed as

Intubation, IntratrachealBiomarkersBody FluidsCross-Sectional StudiesEarly DiagnosisFemaleHumansInfant, NewbornLipopolysaccharide ReceptorsMalePeptide FragmentsPneumonia, BacterialPneumonia, Ventilator-AssociatedTracheaBiomarkersLipopolysaccharide ReceptorsPeptide Fragmentspresepsin protein, humanEarly neonatal pneumonaIntubated newbornsPresepsinTracheal aspirate

Identifiers

PMID29654571

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.