ArticleMetabolic brain disease2018
Cortical and subcortical gray matter structural alterations in normoglycemic obese and type 2 diabetes patients: relationship with adiposity, glucose, and insulin.
Article in Metabolic brain disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Ginseng Bioactive Components as Gut-Brain Axis-Targeted Modulators: Therapeutic Potential and Mechanisms in Multifactorial Diseases.Nutrients · 2026Pooled it
- Altered cortical thickness in type 2 diabetes mellitus patients revealed by coordinate-based meta-analysis.BMC endocrine disorders · 2026Pooled it
- Pooled it
- A systematic review of the impact of type 2 diabetes on brain cortical thickness.Frontiers in dementia · 2024Pooled it
- Glymphatic dysfunction is associated with hyperglycemia-related cortical thinning in patients with type 2 diabetes mellitus.Journal of endocrinological investigation · 2026Article
- Article
- Relationship between body mass index, gray matter volume and peripheral inflammation in patients with post-COVID condition.Brain, behavior, & immunity - health · 2025Article
- A magnetic resonance imaging and gut flora-based study of intake desire in overweight/obese type 2 diabetes mellitus patients.Frontiers in neuroscience · 2025Article
- Altered Subcortical Brain Volume and Cortical Thickness Related to Insulin Resistance in Type 2 Diabetes Mellitus.Brain and behavior · 2024Article
- The impact of metabolic syndrome on the cerebral cortex: a Mendelian randomization study.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- The interplay between white adipose tissue, adipokines, and structural gray matter changes.Human brain mapping · 2024Article
- Childhood maltreatment influences adult brain structure through its effects on immune, metabolic, and psychosocial factors.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Effects of hypertension on subcortical nucleus morphological alternations in patients with type 2 diabetes.Frontiers in endocrinology · 2023Observational
- Obesity and brain structure in schizophrenia - ENIGMA study in 3021 individuals.Molecular psychiatry · 2022Article
- Alteration of brain nuclei in obese children with and without Prader-Willi syndrome.Frontiers in neuroinformatics · 2022Article
- Brain structural abnormalities in obesity: relation to age, genetic risk, and common psychiatric disorders : Evidence through univariate and multivariate mega-analysis including 6420 participants from the ENIGMA MDD working group.Molecular psychiatry · 2021Article
- The association between body mass index and brain morphology in children: a population-based study.Brain structure & function · 2021Article
- Altered Gray Matter Volume, Functional Connectivity, and Degree Centrality in Early-Onset Type 2 Diabetes Mellitus.Frontiers in neurology · 2021Article
- Structural Brain Changes Associated with Overweight and Obesity.Journal of obesity · 2021Review
- Central Obesity, Cardiometabolic Risk, and Cognitive Change in the Study of Latinos - Investigation of Neurocognitive Aging.Journal of Alzheimer's disease : JAD · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type 2 diabetes (T2DM) is associated with structural cortical and subcortical alterations, although it is insufficiently clear if these alterations are driven by obesity or by diabetes and its associated complications. We used FreeSurfer5.3 and FSL-FIRST to determine cortical thickness, volume and surface area, and subcortical gray matter volume in a group of 16 normoglycemic obese subjects and 28 obese T2DM patients without clinically manifest micro- and marcoangiopathy, and compared them to 31 lean normoglycemic controls. Forward regression analysis was used to determine demographic and clinical correlates of altered (sub)cortical structure. Exploratively, vertex-wise correlations between cortical structure and fasting glucose and insulin were calculated. Compared with controls, obese T2DM patients showed lower right insula thickness and lower left lateral occipital surface area (P
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.